MKT 077

Name: MKT 077
Brand: Tocris Bioscience
SKU: 4621

Tocris Bioscience, part of Bio-Techne | Catalog # 4621

Citations (5)

COA / SDS

Binds mot-2; selectively cytotoxic in cancer cells

Key Product Details

Description:	Binds mot-2; selectively cytotoxic in cancer cells
Chemical Name:	1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride
Purity:	≥98% (HPLC)
Molecular Weight:	432

View Full Technical Details for MKT 077

Technical Data
Citations

Biological Activity for MKT 077

MKT 077 is an occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin.

Technical Data for MKT 077

M. Wt	432
Formula	C₂₁H₂₂ClN₃OS₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	147366-41-4
PubChem ID	3037933
InChi Key	VSKYOTRJSLYFHX-UXJRWBAGSA-M
Smiles	CN(C1=CC=CC=C1S2)/C2=C4/C(N(CC)/C(S4)=C\C3=CC=CC=[N+]3CC)=O.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MKT 077

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	21.6	50
	DMSO	21.6	50

Preparing Stock Solutions for MKT 077

The following data is based on the product molecular weight 432.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.63 mL	23.15 mL	46.30 mL
2.5 mM	0.93 mL	4.63 mL	9.26 mL
5 mM	0.46 mL	2.31 mL	4.63 mL
25 mM	0.09 mL	0.46 mL	0.93 mL

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References for MKT 077

References are publications that support the biological activity of the product.

Patury Pharmacological targeting of the Hsp70 chaperone. Curr.Top.Med.Chem. 2009 PMID: 19860737
Wadhwa Rhodacyanine dye MKT-077 inhibits in vitro telomerase activity but has no detectable effects on telomerase activity in vivo. Cancer Res. 2002 PMID: 12154051
Tikoo Treatment of Ras-induced cancers by the F-actin cappers tensin and chaetoglobosin K, in combination with the caspase-1 inhibitor N1445. Cancer J.Sci.Am. 1999 PMID: 10526670
Wadhwa Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res. 2000 PMID: 11156371