MKT 077
Tocris Bioscience, part of Bio-Techne | Catalog # 4621
Binds mot-2; selectively cytotoxic in cancer cells
Key Product Details
Description
Binds mot-2; selectively cytotoxic in cancer cells
Product Description
MKT 077 is an occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin.Product Specifications
Molecular Weight
432.00
Formula
C21H22ClN3OS2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride
CAS Number
147366-41-4
PubChem ID
3037933
InChI Key
VSKYOTRJSLYFHX-UXJRWBAGSA-M
SMILES
CN(C1=CC=CC=C1S2)/C2=C4/C(N(CC)/C(S4)=C\C3=CC=CC=[N+]3CC)=O.[Cl-]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 21.6 | 50 | |
| DMSO | 21.6 | 50 |
Preparing Stock Solutions
for MKT 077
The following data is based on the product molecular weight 432.00
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.63 mL | 23.15 mL | 46.30 mL |
| 2.5 mM | 0.93 mL | 4.63 mL | 9.26 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.63 mL |
| 25 mM | 0.09 mL | 0.46 mL | 0.93 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Patury Pharmacological targeting of the Hsp70 chaperone. Curr.Top.Med.Chem. 2009 PMID: 19860737
- Wadhwa Rhodacyanine dye MKT-077 inhibits in vitro telomerase activity but has no detectable effects on telomerase activity in vivo. Cancer Res. 2002 PMID: 12154051
- Tikoo Treatment of Ras-induced cancers by the F-actin cappers tensin and chaetoglobosin K, in combination with the caspase-1 inhibitor N1445. Cancer J.Sci.Am. 1999 PMID: 10526670
- Wadhwa Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res. 2000 PMID: 11156371
Product Specific Notices for MKT 077
For research use only
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