MK6-83

Name: MK6-83
Brand: Tocris Bioscience
SKU: 5547

Tocris Bioscience, part of Bio-Techne | Catalog # 5547

Citations (11)

COA / SDS

TRPML channel activator

Key Product Details

Description:	TRPML channel activator
Chemical Name:	5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	336.47

View Full Technical Details for MK6-83

Technical Data
Citations

Biological Activity for MK6-83

MK6-83 is a TRPML channel activator (EC₅₀ = 110 nM). Also activates F408Δ and F465L TRPML mutants (EC₅₀ values are 0.1 and 1.23 μM respectively). Restores endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts.

Technical Data for MK6-83

M. Wt	336.47
Formula	C₁₆H₂₀N₂O₂S₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1062271-24-2
PubChem ID	18191179
InChi Key	IRGYSXZCDAWOOC-UHFFFAOYSA-N
Smiles	CC3=CC=C(S3)S(NC1=CC=CC=C1N2CCCCC2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MK6-83

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.65	100
	ethanol	3.36	10

Preparing Stock Solutions for MK6-83

The following data is based on the product molecular weight 336.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.97 mL	14.86 mL	29.72 mL
5 mM	0.59 mL	2.97 mL	5.94 mL
10 mM	0.30 mL	1.49 mL	2.97 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

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References for MK6-83

References are publications that support the biological activity of the product.

Chen A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nat.Commun. 2014 PMID: 25119295