MK6-83
Tocris Bioscience, part of Bio-Techne | Catalog # 5547
TRPML channel activator
Product Description
MK6-83 is a TRPML channel activator (EC50 = 110 nM). Also activates F408Δ and F465L TRPML mutants (EC50 values are 0.1 and 1.23 μM respectively). Restores endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts.Product Specifications
Molecular Weight
336.47
Formula
C16H20N2O2S2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide
CAS Number
1062271-24-2
PubChem ID
18191179
InChI Key
IRGYSXZCDAWOOC-UHFFFAOYSA-N
SMILES
CC3=CC=C(S3)S(NC1=CC=CC=C1N2CCCCC2)(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.65 | 100 | |
| Ethanol | 3.36 | 10 |
Preparing Stock Solutions
for MK6-83
The following data is based on the product molecular weight 336.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.97 mL | 14.86 mL | 29.72 mL |
| 5 mM | 0.59 mL | 2.97 mL | 5.94 mL |
| 10 mM | 0.30 mL | 1.49 mL | 2.97 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.59 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chen A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nat.Commun. 2014 PMID: 25119295
Product Specific Notices for MK6-83
For research use only
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