MK 386

Tocris Bioscience, part of Bio-Techne | Catalog # 5842

Potent, selective human type 1 5α-reductase inhibitor
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Key Product Details

Description

Potent, selective human type 1 5α-reductase inhibitor

View all Other Reductase Inhibitors »

Product Description

MK 386 is a potent and selective human type 1 5α-reductase inhibitor (5αR1, IC50 = 0.9 nM). Exhibits 100-fold selectivity for 5αR1 over 5αR2 (IC50 = 154 nM). Supresses human serum and sebum dihydrotestosterone (DHT) levels in a dose-dependent manner without affecting semen DHT concentrations. Orally active.

Product Specifications

Molecular Weight

415.69

Formula

C28H49NO

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(4aR,4bS,6aR,7R,9aS,9bS,10S,11aR)-7-[(1R)-1,5-Dimethylhexyl]hexadecahydro-1,4a,6a,10-tetramethyl-2H-indeno[5,4-f]quinolin-2-one

CAS Number

158493-17-5

PubChem ID

178013

InChI Key

XUTZDXHKQDPUMA-UHFFFAOYSA-N

SMILES

[H][C@]1([C@@H](CCCC(C)C)C)CC[C@]2([C@@]3([C@H](C[C@]4(N(C(CC[C@@]4([C@]3(CC[C@]12C)[H])C)=O)C)[H])C)[H])[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.57 100

Preparing Stock Solutions for MK 386

The following data is based on the product molecular weight 415.69

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.03 mL 24.06 mL
5 mM 0.48 mL 2.41 mL 4.81 mL
10 mM 0.24 mL 1.20 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Calculators

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Reconstitution Calculator

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Product Documents for MK 386

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MK 386

For research use only

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