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(-)-Xestospongin C

Catalog # 1280 | Tocris Bioscience a Bio-Techne Brand
Reported inhibitor of IP3-dependent Ca2+ release
Reported inhibitor of IP3-dependent Ca2+ release
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Key Product Details

Description: Reported inhibitor of IP3-dependent Ca2+ release
Alternative Names: XeC
Chemical Name: (1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine
Molecular Weight: 446.71

Citations for (-)-Xestospongin C (16)

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Customer Reviews for (-)-Xestospongin C (3)

4.7 out of 5
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  • test
    Name: Mohammad Alqudah
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Smooth muscle
    Used to inhibit IP3 receptors in smooth muscle strips in an organ bath at 10 uM
    (-)-Xestospongin C Serum 1280
  • Used in inhibitor cocktail
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Retinal rod bipolar cells
    Retinal dissections were performed in HEPES-buffered extracellular solution containing glutamate inhibitor cocktail - 1 umol/L
    (-)-Xestospongin C Serum 1280
  • Blocker of IP3 channels
    Name: Sergiy Sylantyev
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampus
    We used (-)-Xestospongin C (XeC) to block calcium release from endoplasmic reticulum via IP3 channels in presynaptic neurons. As a result, LPI, agonist of GPR55 receptor, failed to induce an increase of neurotransmitter release, since this process is calcium-dependent. As a sequence, after application of XeC there was no augmentation of the amplitude of evoked post-synaptic response in postsynaptic neuron: see image.
    (-)-Xestospongin C Serum 1280

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Product Documents for (-)-Xestospongin C

Certificate of Analysis

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