Miglustat hydrochloride

Name: Miglustat hydrochloride
Brand: Tocris Bioscience
SKU: 3117

Tocris Bioscience a Bio-Techne Brand

Catalog # 3117

Citations (1)

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Key Product Details

Description:	α-glucosidase I and II inhibitor; also inhibits ceramide-specific glycosyltransferases and exhibits broad spectrum antiviral activity
Alternative Names:	N-Butyldeoxynojirimycin hydrochloride, NB-DNJ
Chemical Name:	(2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-3,4,5-piperidinetriol hydrochloride
Molecular Weight:	255.74

View Full Technical Details for Miglustat hydrochloride

Biological Activity for Miglustat hydrochloride

Miglustat hydrochloride is an orally active α-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER α-glucosidases I and II. Also has broad spectrum antiviral activity.

Technical Data for Miglustat hydrochloride

M. Wt	255.74
Formula	C₁₀H₂₁NO₄.HCl
Storage	Desiccate at -20°C
CAS Number	210110-90-0
PubChem ID	657399
InChi Key	QPAFAUYWVZMWPR-ZSOUGHPYSA-N
Smiles	CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Miglustat hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	19.18	75
	DMSO	19.18	75

Preparing Stock Solutions for Miglustat hydrochloride

The following data is based on the product molecular weight 255.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	5.21 mL	26.07 mL	52.14 mL
3.75 mM	1.04 mL	5.21 mL	10.43 mL
7.5 mM	0.52 mL	2.61 mL	5.21 mL
37.5 mM	0.10 mL	0.52 mL	1.04 mL

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References for Miglustat hydrochloride

References are publications that support the biological activity of the product.

Noel Parallel improvements of sodium and chloride transport defects by migl. (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells. J.Pharmacol.Exp.Ther. 2008 PMID: 18309088
Dwek Targeting glycosylation as a therapeutic approach. Nat.Rev.Drug Disc. 2002 PMID: 12119611
Platt N-Butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis. J.Biol.Chem. 1994 PMID: 8132559

Citations for Miglustat hydrochloride (1)

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Citations are publications that use Bio-Techne products. Selected citations for Miglustat hydrochloride include:

Huang et al. (2011) Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis. FASEB J. 25:3661
PMID: 21705667

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