Miglitol

Name: Miglitol
Brand: Tocris Bioscience
SKU: 4985

Tocris Bioscience a Bio-Techne Brand

Catalog # 4985

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Key Product Details

Description:	α-glucosidase inhibitor
Alternative Names:	Bay m1009
Chemical Name:	(2R,3R,4R,5S)-1-(2-Hydroxyethyl)-2-(2-hydroxymethyl)-3,4,5-piperidinetriol
Purity:	≥98% (HPLC)
Molecular Weight:	207.22

View Full Technical Details for Miglitol

Biological Activity for Miglitol

Miglitol is an inhibitor of α-glucosidase; antihyperglycemic. Suppresses postprandial hyperglycemia in vivo and reduces plasma glucose concentration in normal rats and in several animal models of diabetes. Shown to inhibit the loss of pancreatic β cells in type 2 diabetic rats. Also inhibits apoptosis and mitochondrial overproduction of reactive oxygen species in endothelial cells in vitro.

Compound Libraries for Miglitol

Miglitol is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Miglitol

M. Wt	207.22
Formula	C₈H₁₇NO₅
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	72432-03-2
PubChem ID	441314
InChi Key	IBAQFPQHRJAVAV-ULAWRXDQSA-N
Smiles	OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Miglitol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	20.72	100
	DMSO	20.72	100

Preparing Stock Solutions for Miglitol

The following data is based on the product molecular weight 207.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.83 mL	24.13 mL	48.26 mL
5 mM	0.97 mL	4.83 mL	9.65 mL
10 mM	0.48 mL	2.41 mL	4.83 mL
50 mM	0.10 mL	0.48 mL	0.97 mL

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References for Miglitol

References are publications that support the biological activity of the product.

Aoki Miglitol, an anti-diabetic drug, inhibits oxdiative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase. J.Pharmacol.Sci. 2012 PMID: 23018899
Goda Effects of miglitol, an α-glucosidase inhibitor, on glycaemic staus and histopathological changes in islets in non-obese, non-Ins-dependent diabetic Goto-Kakizaki rats. Br.J.Nutr. 2007 PMID: 17537288
Sels Miglitol, a new α-glucosidase inhibitor. Expert.Opin.Pharmacother. 1999 PMID: 11249557

Citations for Miglitol

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