MI 14
Tocris Bioscience, part of Bio-Techne | Catalog # 5604
Potent and selective PI 4-kinase IIIβ inhibitor
Key Product Details
Description
Potent and selective PI 4-kinase IIIβ inhibitor
Product Description
MI 14 is a potent and selective PI 4-K IIIβ inhibitor (IC50 = 54 nM). Exhibits >1,800-fold selectivity for PI 4-K IIIβ over PI 4-K IIIα and PI 4-K IIα, respectively. Exhibits antiviral activity against single-stranded positive sense RNA viruses in HeLa cell-based assays.Product Specifications
Molecular Weight
450.94
Formula
C19H23ClN6O3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-[[6-Chloro-3-[3-[(dimethylamino)sulfonyl]phenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]acetamide
CAS Number
1715934-43-2
PubChem ID
91758319
InChI Key
PSTAJIONBVMKLA-UHFFFAOYSA-N
SMILES
CC2=C(C3=CC=CC(S(N(C)C)(=O)=O)=C3)N1N=C(Cl)C=C(NCCNC(C)=O)C1=N2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.02 | 20 |
Preparing Stock Solutions
for MI 14
The following data is based on the product molecular weight 450.94
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 11.09 mL | 55.44 mL | 110.88 mL |
| 1 mM | 2.22 mL | 11.09 mL | 22.18 mL |
| 2 mM | 1.11 mL | 5.54 mL | 11.09 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.22 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mejdrová Highly selective phosphatidylinositol 4-kinase IIIβ inhibitors and structural insight into their mode of action. J.Med.Chem. 2015 PMID: 25897704
Product Specific Notices for MI 14
For research use only
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