MI 14

Name: MI 14
Brand: Tocris Bioscience
SKU: 5604

Tocris Bioscience, part of Bio-Techne | Catalog # 5604

Citations (3)

COA / SDS

Potent and selective PI 4-kinase IIIβ inhibitor

Key Product Details

Description:	Potent and selective PI 4-kinase IIIβ inhibitor
Chemical Name:	N-[2-[[6-Chloro-3-[3-[(dimethylamino)sulfonyl]phenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	450.94

View Full Technical Details for MI 14

Technical Data
Citations

Biological Activity for MI 14

MI 14 is a potent and selective PI 4-K IIIβ inhibitor (IC₅₀ = 54 nM). Exhibits >1,800-fold selectivity for PI 4-K IIIβ over PI 4-K IIIα and PI 4-K IIα, respectively. Exhibits antiviral activity against single-stranded positive sense RNA viruses in HeLa cell-based assays.

Compound Libraries for MI 14

MI 14 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for MI 14

M. Wt	450.94
Formula	C₁₉H₂₃ClN₆O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1715934-43-2
PubChem ID	91758319
InChi Key	PSTAJIONBVMKLA-UHFFFAOYSA-N
Smiles	CC2=C(C3=CC=CC(S(N(C)C)(=O)=O)=C3)N1N=C(Cl)C=C(NCCNC(C)=O)C1=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MI 14

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.02	20

Preparing Stock Solutions for MI 14

The following data is based on the product molecular weight 450.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.09 mL	55.44 mL	110.88 mL
1 mM	2.22 mL	11.09 mL	22.18 mL
2 mM	1.11 mL	5.54 mL	11.09 mL
10 mM	0.22 mL	1.11 mL	2.22 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for MI 14

References are publications that support the biological activity of the product.

Mejdrová Highly selective phosphatidylinositol 4-kinase IIIβ inhibitors and structural insight into their mode of action. J.Med.Chem. 2015 PMID: 25897704