Mexiletine hydrochloride

Name: Mexiletine hydrochloride
Brand: Tocris Bioscience
SKU: 2596

Tocris Bioscience, part of Bio-Techne | Catalog # 2596

Citations (5)

COA / SDS

Na+ channel blocker; antiarrhythmic agent

Key Product Details

Description:	Na⁺ channel blocker; antiarrhythmic agent
Alternative Names:	Ko 1173
Chemical Name:	1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	215.72

View Full Technical Details for Mexiletine hydrochloride

Technical Data
Citations

Biological Activity for Mexiletine hydrochloride

Mexiletine hydrochloride is an use-dependent sodium channel blocker (IC₅₀ values are 75.3 and 23.6 μM for tonic and use-dependent block respectively). Class Ib antiarrhythmic, neuroprotective and antimyotonic agent.

Compound Libraries for Mexiletine hydrochloride

Mexiletine hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Mexiletine hydrochloride

M. Wt	215.72
Formula	C₁₁H₁₇NO.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	5370-01-4
PubChem ID	21467
InChi Key	NFEIBWMZVIVJLQ-UHFFFAOYSA-N
Smiles	Cl.CC(N)COC1=C(C)C=CC=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Mexiletine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	21.57	100
	DMSO	21.57	100

Preparing Stock Solutions for Mexiletine hydrochloride

The following data is based on the product molecular weight 215.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.64 mL	23.18 mL	46.36 mL
5 mM	0.93 mL	4.64 mL	9.27 mL
10 mM	0.46 mL	2.32 mL	4.64 mL
50 mM	0.09 mL	0.46 mL	0.93 mL

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Reconstitution Calculator

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References for Mexiletine hydrochloride

References are publications that support the biological activity of the product.

Ates Neuroprotective effect of mexil. in the central nervous system of diabetic rats. Mol.Cell.Biochem. 2006 PMID: 16541198
Bellis Evaluation of the pharmacological activity of the major mexil. metabolites on skeletal muscle sodium currents. Br.J.Pharmacol. 2006 PMID: 16921388
Franchini Optically active mexil. analogues as stereoselective blockers of voltage-gated Na⁺ channels. J.Med.Chem. 2003 PMID: 14613326