Metoprolol tartrate

Name: Metoprolol tartrate
Brand: Tocris Bioscience
SKU: 3256

Tocris Bioscience, part of Bio-Techne | Catalog # 3256

Citations (7)

COA / SDS

Selective β1 antagonist

Key Product Details

Description:	Selective β₁ antagonist
Chemical Name:	1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemitartrate
Purity:	≥98% (HPLC)
Molecular Weight:	342.4

View Full Technical Details for Metoprolol tartrate

Technical Data
Citations

Biological Activity for Metoprolol tartrate

Metoprolol tartrate is a selective β₁-adrenoceptor antagonist (K_i values are 47, 2960 and 10100 nM for β₁, β₂ and β₃ adrenoceptors respectively). Inhibits spontaneous endothelin-1 production in vitro and displays antihypertensive and antianginal activity in vivo.

Compound Libraries for Metoprolol tartrate

Metoprolol tartrate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Metoprolol tartrate

M. Wt	342.4
Formula	C₁₅H₂₅NO₃.½C₄H₆O₆
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	56392-17-7
PubChem ID	6420057
InChi Key	YGULWPYYGQCFMP-UHFFFAOYSA-N
Smiles	O=C(O)C(O)C(O)C(O)=O.OC(CNC(C)C)COC1=CC=C(CCOC)C=C1.OC(CNC(C)C)COC2=CC=C(CCOC)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Metoprolol tartrate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	34.24	100
	DMSO	34.24	100

Preparing Stock Solutions for Metoprolol tartrate

The following data is based on the product molecular weight 342.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.92 mL	14.60 mL	29.21 mL
5 mM	0.58 mL	2.92 mL	5.84 mL
10 mM	0.29 mL	1.46 mL	2.92 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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References for Metoprolol tartrate

References are publications that support the biological activity of the product.

Dasbiswas S-metoprolol: The 2008 Clinical Review. J.Indian.Med.Assoc. 2008 PMID: 18828349
Hoffmann Comparative pharmacology of human β-adrenergic receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn-Schmied.Arch.Pharmacol. 2004 PMID: 14730417
Garlichs Beta-blockers reduce the release and synthesis of endothelin-1 in human endothelial cells. Eur.J.Clin.Invest. 1999 PMID: 10092983