Methylprednisolone
Tocris Bioscience, part of Bio-Techne | Catalog # 4819
Glucocorticoid receptor agonist
Key Product Details
Description
Glucocorticoid receptor agonist
Product Description
Methylprednisolone is a glucocorticoid receptor (GR) agonist. Displays anti-inflammatory and antioxidant properties. Attenuates apoptosis in oligodendrocytes after injury stimuli. Upregulates expression of Bcl-xL via direct binding of the GR/STAT5 complex. Neuroprotective.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
374.47
Formula
C22H30O5
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
11β,17β,21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione
CAS Number
83-43-2
PubChem ID
6741
InChI Key
VHRSUDSXCMQTMA-PJHHCJLFSA-N
SMILES
O=C1C=C[C@@]2(C)C([C@@H](C)C[C@]3([H])[C@@]([H])2[C@@H](O)C[C@@]4(C)[C@]([H])3CC[C@](C(CO)=O)4O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.45 | 100 |
Preparing Stock Solutions
for Methylprednisolone
The following data is based on the product molecular weight 374.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.67 mL | 13.35 mL | 26.70 mL |
| 5 mM | 0.53 mL | 2.67 mL | 5.34 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.67 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Xu STAT5 mediates antiapoptotic effects of methylprednis. on oligodendrocytes. J.Neurosci. 2009 PMID: 19228956
- Lee Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury. J.Neurosci. 2008 PMID: 18354017
Product Specific Notices for Methylprednisolone
For research use only
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