Methyllycaconitine citrate
Tocris Bioscience a Bio-Techne Brand
Key Product Details
Description: | Selective α7 neuronal nAChR antagonist |
Alternative Names: | MLA |
Chemical Name: | [1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diol citrate |
Purity: | ≥95% (HPLC) |
Molecular Weight: | 874.93 |
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Citations for Methyllycaconitine citrate (30)
Citations are publications that use Bio-Techne products. Selected citations for Methyllycaconitine citrate include:
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Garton et al.
(2019)
Amphetamine enantiomers inhibit homomeric α7 nicotinic receptor through a competitive mechanism and within the intoxication levels in humans.
Neuropharmacology.
144:172
PMID: 30359640 -
Lozovaya et al.
(2018)
GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease.
Nat Commun.
9(1):1422
PMID: 29651049 -
Muñoz et al.
(2018)
Alcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum.
Nat Commun.
9:1318
PMID: 29615610 -
Assous
(2017)
Differential processing of thalamic information via distinct striatal interneuron circuits.
Nat Commun.
8:15860
PMID: 28604688 -
Zhang et al.
(2016)
Acetylcholinesterase inhibitors for Alzheimer's disease treatment ameliorate acetaminophen-induced liver injury in mice via central cholinergic system regulation
the Journal of Pharmacology and Experimental Thera.
2016;
PMID: 27535978 -
Herman et al.
(2016)
A cholinergic basal forebrain feeding circuit modulates appetite suppression
Nature.
538:253
PMID: 27698417 -
Saunders et al.
(2015)
Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
Neurochem Res.
4
PMID: 25723967 -
Tang et al.
(2015)
Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex.
PLoS One.
5:14099
PMID: 26370265 -
Pinnock et al.
(2015)
Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine.
Arch Neurol.
9:30
PMID: 25717295 -
Elgueta et al.
(2015)
Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells.
J Neurosci.
9:6
PMID: 25709566 -
Brown and Wonnacott
(2015)
Sazetidine-A Activates and Desensitizes Native α7 Nicotinic Acetylcholine Receptors.
Sci Rep.
40:2047
PMID: 24728867 -
Dannenberg et al.
(2015)
Synergy of direct and indirect cholinergic septo-hippocampal pathways coordinates firing in hippocampal networks.
J Neurosci.
35:8394
PMID: 26041909 -
Kiss et al.
(2014)
Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle.
PLoS One.
9:e109538
PMID: 25303328 -
Kim et al.
(2014)
Stimulation of the α7 nicotinic acetylcholine receptor protects against sepsis by inhibiting Toll-like receptor via phosphoinositide 3-kinase activation.
J Infect Dis.
209:1668
PMID: 24298024 -
Callahan et al.
(2013)
Positive allosteric modulator of α7 nicotinic-acetylcholine receptors, PNU-120596 augments the effects of donep. on learning and memory in aged rodents and non-human primates.
Neuropharmacology.
67:201
PMID: 23168113 -
Brown et al.
(2013)
Nicotine induces the up-regulation of the α7-nicotinic receptor (α7-nAChR) in human squamous cell lung cancer cells via the Sp1/GATA protein pathway.
J Biol Chem.
288:33049
PMID: 24089524 -
Némethova et al.
(2013)
Nicotine attenuates activation of tissue resident macrophages in the mouse stomach through the β2 nicotinic acetylcholine receptor.
Front Behav Neurosci.
8:e79264
PMID: 24223920 -
Hogenkamp et al.
(2013)
Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type I positive allosteric modulators of α7 nicotinic acetylcholine receptors.
J Med Chem.
56:8352
PMID: 24098954 -
Leão et al.
(2012)
OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons.
Nat Neurosci.
15:1524
PMID: 23042082 -
Grimster et al.
(2012)
Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template.
J Am Chem Soc.
134:6732
PMID: 22394239 -
Yamauchi et al.
(2012)
Synthesis of selective agonists for the α7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templates.
J Pharmacol Exp Ther.
82:687
PMID: 22784805 -
Northrop et al.
(2011)
Regulation of glutamate release by α7 nicotinic receptors: differential role in methamphetamine-induced damage to DArgic and serotonergic terminals.
Am J Physiol Renal Physiol.
336:900
PMID: 21159748 -
Lecca et al.
(2011)
Effects of drugs of abuse on putative rostromedial tegmental neurons, inhibitory afferents to midbrain DA cells.
Neuropsychopharmacology.
36:589
PMID: 21048703 -
Li et al.
(2010)
Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors.
Auton Neurosci.
154:14
PMID: 19887306 -
Collins and Millar
(2010)
Nicotinic acetylcholine receptor transmembrane mutations convert iverm. from a positive to a negative allosteric modulator.
Mol Pharmacol.
78:198
PMID: 20463059 -
Huang and Hsu
(2010)
Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex.
Cereb Cortex.
20:982
PMID: 19666830 -
Li et al.
(2009)
Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses.
Neurosci Lett.
462:20
PMID: 19573576 -
Ikonomovic et al.
(2009)
Cortical α7 nicotinic acetylcholine receptor and β-amyloid levels in early Alzheimer disease.
Mol Pharmacol.
66:646
PMID: 19433665 -
Beckel et al.
(2006)
Expression of functional nicotinic acetylcholine receptors in rat urinary bladder epithelial cells.
Front Cell Neurosci.
290:F103
PMID: 16144967 -
Hansen et al.
(2005)
Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations.
EMBO J.
24:3635
PMID: 16193063
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