Methyllycaconitine citrate

Name: Methyllycaconitine citrate
Brand: Tocris Bioscience
SKU: 1029
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1029

(1)

Citations (97)

COA / SDS

Selective α7 neuronal nAChR antagonist

Key Product Details

Description:	Selective α7 neuronal nAChR antagonist
Alternative Names:	MLA
Chemical Name:	[1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diol citrate
Purity:	≥95% (HPLC)
Molecular Weight:	874.93

View Full Technical Details for Methyllycaconitine citrate

Technical Data
Citations / Reviews (1)

Biological Activity for Methyllycaconitine citrate

Methyllycaconitine citrate is a potent antagonist for α7-containing neuronal nicotinic receptors (K_i = 1.4 nM). Interacts with α4β2 and α6β2 receptors at concentrations > 40 nM. Attenuates METH-induced neurotoxicity in mouse striatum in vivo.

Technical Data for Methyllycaconitine citrate

M. Wt	874.93
Formula	C₃₇H₅₀N₂O₁₀.C₆H₈O₇
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	351344-10-0
PubChem ID	90479749
InChi Key	INBLZNJHDLEWPS-IRPACCRLSA-N
Smiles	OC(=O)CC(O)(CC(O)=O)C(O)=O.[H][C@@]12C[C@H]3[C@H](OC)[C@]1([H])[C@](O)(C[C@@H]3OC)[C@]1(O)[C@@H](OC)C3[C@@]22[C@H]1N(CC)C[C@]3(COC(=O)C1=CC=CC=C1N1C(=O)C[C@H](C)C1=O)CC[C@@H]2OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Methyllycaconitine citrate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	87.49	100
	DMSO	87.49	100

Preparing Stock Solutions for Methyllycaconitine citrate

The following data is based on the product molecular weight 874.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.14 mL	5.71 mL	11.43 mL
5 mM	0.23 mL	1.14 mL	2.29 mL
10 mM	0.11 mL	0.57 mL	1.14 mL
50 mM	0.02 mL	0.11 mL	0.23 mL

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Reconstitution Calculator

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References for Methyllycaconitine citrate

References are publications that support the biological activity of the product.

Escubedo Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum: involvement of α7 nicotinic receptors. J.Pharmacol.Exp.Ther. 2005 PMID: 16076935
Ward Methyllycaconitine: a selective probe for neuronal a-bungarotoxin binding sites. FEBS Lett. 1990 PMID: 2226787
Dobelis Effects of delphinium alkaloids on neuromuscular transmission. J.Pharmacol.Exp.Ther. 1999 PMID: 10525069