Mesulergine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1644
5-HT2A and 5-HT2C antagonist; also D2-like partial agonist
Key Product Details
Description
5-HT2A and 5-HT2C antagonist; also D2-like partial agonist
Alternative Names
CU-32-085
Product Description
Mesulergine hydrochloride is a 5-HT2A and 2C receptor antagonist (pA2 values are 9.1 for each receptor) and D2-like dopamine receptor partial agonist (Ki = 8 nM). Displays antiprolactin and antiparkinsonian effects in vivo.Product Specifications
Molecular Weight
398.95
Formula
C18H26N4O2S.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N'-[(8-α1,6-dimethylergolin-8-yl]-N,N-dimethylsulfamide hydrochloride
CAS Number
72786-12-0
PubChem ID
155746
InChI Key
HANSYUJEPWNHIM-IVMONYBCSA-N
SMILES
CN2C1=CC=CC([C@]4([H])[C@@](N(C)C[C@@H](NS(=O)(N(C)C)=O)C4)([H])C3)=C1C3=C2.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 1.99 | 5 with gentle warming | |
| DMSO | 39.9 | 100 |
Preparing Stock Solutions
for Mesulergine hydrochloride
The following data is based on the product molecular weight 398.95
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.51 mL | 12.53 mL | 25.07 mL |
| 5 mM | 0.50 mL | 2.51 mL | 5.01 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.51 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Marko DA agonistic potency of two novel prolactin release-inhibiting ergolines. Eur.J.Pharmacol. 1984 PMID: 6468500
- Markstei Mesulergine and its 1,20-N,N-bidemethylated metabolite interact directly with D1- and D2-receptors. Eur.J.Pharmacol. 1983 PMID: 6230246
- Hoyer VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 1994 PMID: 7938165
Product Specific Notices for Mesulergine hydrochloride
For research use only
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