Megestrol Acetate

Name: Megestrol Acetate
Brand: Tocris Bioscience
SKU: 6285

Tocris Bioscience, part of Bio-Techne | Catalog # 6285

Citations (2)

COA / SDS

Synthetic progesterone analog

Key Product Details

Description:	Synthetic progesterone analog
Chemical Name:	17-(Acetyloxy)-6-methylpregna-4,6-diene-3,20-dione
Purity:	≥98% (HPLC)
Molecular Weight:	384.51

View Full Technical Details for Megestrol Acetate

Technical Data
Citations

Biological Activity for Megestrol Acetate

Megestrol Acetate is a synthetic progesterone analog. Dose-dependently inhibits growth of HepG2 cells (IC₅₀ = 260 μM) in vitro and in vivo and reduces tumor volume. High dosages improve weight gain in tumor-bearing nude mice. Orally bioavailable.

Compound Libraries for Megestrol Acetate

Megestrol Acetate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Megestrol Acetate

M. Wt	384.51
Formula	C₂₄H₃₂O₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	595-33-5
PubChem ID	11683
InChi Key	RQZAXGRLVPAYTJ-GQFGMJRRSA-N
Smiles	[H][C@@]12CC[C@](C(C)=O)([C@]1(CC[C@]3([C@]2(C=C(C4=CC(CC[C@]34C)=O)C)[H])[H])C)OC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Megestrol Acetate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	19.23	50
	ethanol	7.69	20

Preparing Stock Solutions for Megestrol Acetate

The following data is based on the product molecular weight 384.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.20 mL	26.01 mL	52.01 mL
2.5 mM	1.04 mL	5.20 mL	10.40 mL
5 mM	0.52 mL	2.60 mL	5.20 mL
25 mM	0.10 mL	0.52 mL	1.04 mL

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Reconstitution Calculator

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References for Megestrol Acetate

References are publications that support the biological activity of the product.

Tchekmedyian Megestrol acetate in cancer anorexia and weight loss. Cancer. 1992 PMID: 1739926
Zhang and Chow The effect of mege. acetate on growth of HepG2 cells in vitro and in vivo. Clin.Cancer.Res. 2004 PMID: 15297426

Product Documents for Megestrol Acetate

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Megestrol acetate, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov