Meclizine dihydrochloride

Product Description

Meclizine dihydrochloride is a human pregnane X receptor (hPXR) agonist; it is a more potent activator of hPXR than rat PXR. Meclizine increases hPXR target gene expression in human hepatocyte primary cultures. It also acts as a histamine H₁ receptor antagonist. Meclizine attenuates mitochondrial respiration and increases glycolysis. The product inhibits rotenone-induced cell death in stem cell-derived dopaminergic neuronal culture and confers neuroprotection in models of polyglutamine (polyQ) toxicity.

Solubility

Preparing Stock Solutions for Meclizine dihydrochloride

The following data is based on the product molecular weight 463.87

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.31 mL	21.56 mL	43.12 mL
2.5 mM	0.86 mL	4.31 mL	8.62 mL
5 mM	0.43 mL	2.16 mL	4.31 mL
25 mM	0.09 mL	0.43 mL	0.86 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Oosterveen Pluripotent stem cell derived dopaminergic subpopulations model the selective neuron degeneration in Parkinson's disease. Stem Cell Reports 2021 PMID: 34678205
• Gohil Meclizine is neuroprotective in models of Huntington's disease. Hum.Mol.Genet. 2010 PMID: 20977989
• Lau Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor. J.Pharmacol.Exp.Ther. 2011 PMID: 21131266
• Parada The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception. Neuroscience 2001 PMID: 11182255