MDL 72222

Name: MDL 72222
Brand: tocris
SKU: 0640
Rating: 5 (1 reviews)

Catalog # 0640

Citations (6)

(1)

Datasheet / COA / SDS

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Key Product Details

Description:	5-HT₃ antagonist
Chemical Name:	Tropanyl 3,5-dichlorobenzoate
Purity:	≥99% (HPLC)
Molecular Weight:	314.21

View Full Technical Details for MDL 72222

Biological Activity

5-HT₃ antagonist.

Compound Libraries

MDL 72222 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	314.21
Formula	C₁₅H₁₇Cl₂NO₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	40796-97-2
PubChem ID	1683
InChi Key	MNJNPLVXBISNSX-UHFFFAOYSA-N
Smiles	CN1C2CCC1CC(C2)OC(=O)C1=CC(Cl)=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		100

Preparing Stock Solutions

The following data is based on the product molecular weight 314.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.18 mL	15.91 mL	31.83 mL
5 mM	0.64 mL	3.18 mL	6.37 mL
10 mM	0.32 mL	1.59 mL	3.18 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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References

References are publications that support the biological activity of the product.

Fozard MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors. Naunyn Schmiedebergs Arch.Pharmacol. 1984 PMID: 6472484
Richardson and Engel The pharmacology and function of 5-HT₃ receptors. Trends Neurosci.

Citations (6)

Showing 1- 5 of 6 citations Showing All

Citations are publications that use Bio-Techne products. Selected citations for MDL 72222 include:

Dolma et al. (2016) Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell. 29:859
PMID: 27300435
Bocchio et al. (2015) Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala. Neuropsychopharmacology. 40:3015
PMID: 26052039
Jinka et al. (2012) Inhibition of NMDA-type glutamate receptors induces arousal from torpor in hibernating arctic ground squirrels (Urocitellus parryii). J Neurochem. 122:934
PMID: 22697356
Woo et al. (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron. 54:599
PMID: 17521572
Hampson et al. (2007) Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia. 50:1743
PMID: 17579833
Geerts et al. (1999) Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery. Br J Pharmacol. 127:1327
PMID: 10455282

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Pharmacological block of 5-HT3 receptors

Name: Anonymous

Species: Mouse

Assay Type: Ex Vivo

Cell Line/Tissue: Cerebellum

MDL 72222 was used for pharmacological isolation of glycine receptors response in nucleated membrane patches pulled from cerebellar granule cells. Clear response was obtained, with characteristic conductance states pertinent to glycine receptor. Picture: recording of single-channel openings of glycine receptor with 10 microM MDL 72222 in perfusion solution.

PMID: PMC6487928

MDL 72222

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Biological Activity

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Technical Data

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References

Citations (6)

Customer Reviews (1)

Pharmacological block of 5-HT3 receptors

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