MCU i4
Tocris Bioscience, part of Bio-Techne | Catalog # 7195
Negative modulator of mitochondrial Ca2+ uniporter (MCU)
Key Product Details
Description
Negative modulator of mitochondrial Ca2+ uniporter (MCU)
Product Description
MCU i4 is a negative modulator of mitochondrial calcium (Ca2+) uniporter (MCU) complex, which binds to MICU1, a regulatory protein within MCU complex. MCU i4 reduces mitochondrial Ca2+ uptake in multiple cell lines including MEFs, MDA-MB,231 and HEK293T cells, and demonstrates a negative effect on mitochondrial membrane potential. In ex vivo muscle fibres, MCU i4 reduces mitochondrial Ca2+ uptake and impairs muscle cell growth.Product Specifications
Molecular Weight
377.49
Formula
C23H27N3O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[[4-(Diethylamino)phenyl]amino]-6-methyl-3-quinolinecarboxylic acid ethyl ester
CAS Number
371924-24-2
PubChem ID
1568449
InChI Key
RIWXBJCWHVMATR-UHFFFAOYSA-N
SMILES
CCOC(=O)C1=C(NC2=CC=C(C=C2)N(CC)CC)C2=C(C=CC(C)=C2)N=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.87 | 50 | |
| Ethanol | 37.75 | 100 |
Preparing Stock Solutions
for MCU i4
The following data is based on the product molecular weight 377.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.65 mL | 13.25 mL | 26.49 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.30 mL |
| 10 mM | 0.26 mL | 1.32 mL | 2.65 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Di Marco A high-throughput screening identifies MICU1 targeting compounds. Cell Rep. 2020 PMID: 32075766
Product Specific Notices for MCU i4
For research use only
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