MCU i4

Name: MCU i4
Brand: Tocris Bioscience
SKU: 7195

Tocris Bioscience, part of Bio-Techne | Catalog # 7195

Citations (6)

COA / SDS

Negative modulator of mitochondrial Ca2+ uniporter (MCU)

Key Product Details

Description:	Negative modulator of mitochondrial Ca²⁺ uniporter (MCU)
Chemical Name:	4-[[4-(Diethylamino)phenyl]amino]-6-methyl-3-quinolinecarboxylic acid ethyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	377.49

View Full Technical Details for MCU i4

Technical Data
Citations

Biological Activity for MCU i4

MCU i4 is a negative modulator of mitochondrial calcium (Ca²⁺) uniporter (MCU) complex, which binds to MICU1, a regulatory protein within MCU complex. MCU i4 reduces mitochondrial Ca²⁺ uptake in multiple cell lines including MEFs, MDA-MB,231 and HEK293T cells, and demonstrates a negative effect on mitochondrial membrane potential. In ex vivo muscle fibres, MCU i4 reduces mitochondrial Ca²⁺ uptake and impairs muscle cell growth.

Compound Libraries for MCU i4

MCU i4 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for MCU i4

M. Wt	377.49
Formula	C₂₃H₂₇N₃O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	371924-24-2
PubChem ID	1568449
InChi Key	RIWXBJCWHVMATR-UHFFFAOYSA-N
Smiles	CCOC(=O)C1=C(NC2=CC=C(C=C2)N(CC)CC)C2=C(C=CC(C)=C2)N=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MCU i4

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	18.87	50
	ethanol	37.75	100

Preparing Stock Solutions for MCU i4

The following data is based on the product molecular weight 377.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.65 mL	13.25 mL	26.49 mL
5 mM	0.53 mL	2.65 mL	5.30 mL
10 mM	0.26 mL	1.32 mL	2.65 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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References for MCU i4

References are publications that support the biological activity of the product.

Di Marco A high-throughput screening identifies MICU1 targeting compounds. Cell Rep. 2020 PMID: 32075766