McN-A 343
Tocris Bioscience, part of Bio-Techne | Catalog # 1384
Selective M1 muscarinic agonist
Product Description
McN-A 343 is a selective muscarinic M1 receptor agonist. Selectivity for M1 over other muscarinic receptor types appears to arise from a high efficacy at M1 receptors.Product Specifications
Molecular Weight
317.21
Formula
C14H18Cl2N2O2
Storage
Desiccate at RT
Purity
≥99% (HPLC)
Chemical Name
4-[[[(3-Chlorophenyl)amino]carbonyl]oxy]-N,N,N-trimethyl-2-butyn-1-aminium chloride
CAS Number
55-45-8
PubChem ID
5926
InChI Key
CXFZFEJJLNLOTA-UHFFFAOYSA-N
SMILES
ClC1=CC=CC(NC(OCC#CC[N+](C)(C)C)=O)=C1.[Cl-]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 31.72 | 100 |
Preparing Stock Solutions
for McN-A 343
The following data is based on the product molecular weight 317.21
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.15 mL | 15.76 mL | 31.52 mL |
| 5 mM | 0.63 mL | 3.15 mL | 6.30 mL |
| 10 mM | 0.32 mL | 1.58 mL | 3.15 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Eglen Muscarinic receptor subtypes and smooth muscle function. Pharmacol.Rev. 1996 PMID: 8981565
- Micheletti and Schiavone Functional determination of McN-A-343 affinity for M1 muscarinic receptors. J.Pharmacol.Exp.Ther. 1990 PMID: 1691785
- Davies Inhibition of field stimulation-induced contractions of rabbit vas deferens by muscarinic receptor agonists: selectivity of McN-A-343 for M1 receptors. J.Pharm.Pharmacol. 2001 PMID: 11341365
Product Specific Notices for McN-A 343
For research use only
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