McN-A 343

Name: McN-A 343
Brand: Tocris Bioscience
SKU: 1384

Tocris Bioscience, part of Bio-Techne | Catalog # 1384

Citations (7)

COA / SDS

Selective M1 muscarinic agonist

Key Product Details

Description:	Selective M₁ muscarinic agonist
Chemical Name:	4-[[[(3-Chlorophenyl)amino]carbonyl]oxy]-N,N,N-trimethyl-2-butyn-1-aminium chloride
Purity:	≥99% (HPLC)
Molecular Weight:	317.21

View Full Technical Details for McN-A 343

Technical Data
Citations

Biological Activity for McN-A 343

McN-A 343 is a selective muscarinic M₁ receptor agonist. Selectivity for M₁ over other muscarinic receptor types appears to arise from a high efficacy at M₁ receptors.

Technical Data for McN-A 343

M. Wt	317.21
Formula	C₁₄H₁₈Cl₂N₂O₂
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	55-45-8
PubChem ID	5926
InChi Key	CXFZFEJJLNLOTA-UHFFFAOYSA-N
Smiles	ClC1=CC=CC(NC(OCC#CC[N+](C)(C)C)=O)=C1.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for McN-A 343

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	31.72	100

Preparing Stock Solutions for McN-A 343

The following data is based on the product molecular weight 317.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.15 mL	15.76 mL	31.52 mL
5 mM	0.63 mL	3.15 mL	6.30 mL
10 mM	0.32 mL	1.58 mL	3.15 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

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References for McN-A 343

References are publications that support the biological activity of the product.

Eglen Muscarinic receptor subtypes and smooth muscle function. Pharmacol.Rev. 1996 PMID: 8981565
Micheletti and Schiavone Functional determination of McN-A-343 affinity for M₁ muscarinic receptors. J.Pharmacol.Exp.Ther. 1990 PMID: 1691785
Davies Inhibition of field stimulation-induced contractions of rabbit vas deferens by muscarinic receptor agonists: selectivity of McN-A-343 for M₁ receptors. J.Pharm.Pharmacol. 2001 PMID: 11341365