Marimastat is a broad spectrum inhibitor of MMPs (IC₅₀ values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). Inhibits peritoneal dissemination of human gastric cancer cells in vivo through inhibition of tumor angiogenesis.

Product Specifications

Molecular Weight

331.41

Formula

C₁₅H₂₉N₃O₅

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide

CAS Number

154039-60-8

PubChem ID

119031

InChI Key

OCSMOTCMPXTDND-OUAUKWLOSA-N

SMILES

O=C(NO)[C@@H](O)[C@H]([C@](N[C@@H]([C@](C)(C)C)C(NC)=O)=O)CC(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	33.14	100

Preparing Stock Solutions for Marimastat

The following data is based on the product molecular weight 331.41

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.02 mL	15.09 mL	30.17 mL
5 mM	0.60 mL	3.02 mL	6.03 mL
10 mM	0.30 mL	1.51 mL	3.02 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Wada Reduced angiogenesis in peritoneal dissemination of gastric cancer through gelatinase inhibition. Clin.Exp.Metastasis 2003 PMID: 14524532
Bjornland Matrix metalloproteinases participate in osteosarcoma invasion. J.Surg.Res. 2005 PMID: 16083752
Rasmussen and McCann Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat. Pharmacol.Ther. 1997 PMID: 9364582

Marimastat

Tocris Bioscience, part of Bio-Techne | Catalog # 2631

Key Product Details

Description

Alternative Names

View all Matrix Metalloprotease (MMP) Inhibitors »

Product Description