M871

Catalog # 2698 | Tocris Bioscience a Bio-Techne Brand

Selective GAL2 antagonist

Key Product Details

Description:	Selective GAL₂ antagonist
Alternative Names:	Galanin-(2-13)-Glu-His-(Pro)₃-(Ala-Leu)₂-Ala-amide
Purity:	≥95% (HPLC)
Molecular Weight:	2287.64

View Full Technical Details for M871

Technical Data
Citations (6) / Reviews

Biological Activity for M871

M871 is a selective galanin GAL₂ receptor antagonist (K_i values are 13.1 and 420 nM for GAL₂ and GAL₁ receptors respectively). Blocks the pro-nociceptive effect of GAL₂ receptor agonists.

Technical Data for M871

M. Wt	2287.64
Formula	C₁₀₈H₁₆₃N₂₇O₂₈
Single Letter Sequence	WTLNSAGYLLGPEHPPPALALA (Modification: Ala-22 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	908844-75-7
PubChem ID	90477989
InChi Key	BHKXASDHGWBINL-ZEHYZEGSSA-N
Smiles	[H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for M871

Solubility

Soluble to 1mg/ml in water

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References for M871

References are publications that support the biological activity of the product.

Jimenez-Andrade Activation of peripheral galanin receptors: differential effects on nociception. Pharmacol.Biochem.Behav. 2006 PMID: 16996122
Sollenburg M871 - a novel peptide antagonist selectively recognizing the galanin receptor type 2. Int.J.Pept.Res.Ther.

Citations for M871 (6)

Showing 1 - 6 of 6 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for M871 include:

Funck (2018) Dorsal hippocampal galanin modulates anxiety-like behaviours in rats. Brain Res. 1688:75
PMID: 29499176
Fang (2018) Central galanin receptor 2 mediates galanin action to promote systemic glucose metabolism of type 2 diabetic rats. Biochem Pharmacol. 156:241
PMID: 30170096
Zhang (2017) Involvement of galanin and galanin receptor 2 in nociceptive modulation in anterior cingulatecortex of normal rats and rats with mononeuropathy Sci Rep. 7:45930
PMID: 28378856
Scanlon et al. (2015) Galanin modulates the neural niche to favour perineural invasion in head and neck cancer. Int J Neuropsychopharmacol. 6:6885
PMID: 25917569
Millón et al. (2015) A role for galanin N-terminal fragment (1-15) in anxiety- and depression-related behaviors in rats. Immun Inflamm Dis. 18
PMID: 25522404
Millòn et al. (2014) A role for galanin N-terminal fragment (1-15) in anxiety- and depression-related behaviors in rats. Int.J.Neuropsychopharmacol.. 18
PMID: 25522404

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