M617

Tocris Bioscience, part of Bio-Techne | Catalog # 2697

COA / SDS

Selective GAL1 agonist

Key Product Details

Description:	Selective GAL₁ agonist
Alternative Names:	Galanin(1-13)-Gln¹⁴-bradykinin(2-9)amide
Purity:	≥95% (HPLC)
Molecular Weight:	2361.68

View Full Technical Details for M617

Technical Data
Citations

Biological Activity for M617

M617 is a selective galanin GAL₁ receptor agonist (K_i values are 0.23 and 5.71 nM for GAL₁ and GAL₂ receptors respectively). Enhances food consumption in rats following i.c.v. administration and reduces CAP-induced inflammatory pain.

Technical Data for M617

M. Wt	2361.68
Formula	C₁₁₂H₁₆₁N₂₉O₂₈
Single Letter Sequence	GWTLNSAGYLLGPQPPGFSPFR (Modifications: Arg-22 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	860790-38-1
PubChem ID	16158157
InChi Key	PAYBRARNTYCYOT-OTTBQUPZSA-N
Smiles	[H]NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for M617

Solubility

Soluble to 1mg/ml in water

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References for M617

References are publications that support the biological activity of the product.

Jimenez-Andrade Activation of peripheral galanin receptors: differential effects on nociception. Pharmacol.Biochem.Behav. 2006 PMID: 16996122
Lundstrom A galanin receptor subtype 1 specific agonist. Int.J.Pept.Res.Ther.
Mazarati Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: the effects of subtype-selective agonists and the role of G-protein-mediated signaling. J.Pharmacol.Exp.Ther. 2006 PMID: 16699066