LY 364947

Name: LY 364947
Brand: Tocris Bioscience
SKU: 2718

Tocris Bioscience, part of Bio-Techne | Catalog # 2718

Citations (15)

COA / SDS

Selective inhibitor of TGF-βRI

Discontinued Product

2718 has been discontinued. View all TGF-beta Receptor Inhibitors products.

Key Product Details

Description:	Selective inhibitor of TGF-βRI
Alternative Names:	HTS 466284
Chemical Name:	4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-quinoline
Purity:	≥99% (HPLC)
Molecular Weight:	272.31

View Full Technical Details for LY 364947

Technical Data
Citations

Biological Activity for LY 364947

LY 364947 is a selective inhibitor of TGF-β type-I receptor (TGF-β RI, TGFR-I, TβR-I, ALK-5) (IC₅₀ values are 59, 400 and 1400 nM for TGR-β RI, TGF-β RII and MLK-7K respectively). Inhibits TGF-β-dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC₅₀ values are 47 and 89 nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay.

Compound Libraries for LY 364947

LY 364947 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for LY 364947

M. Wt	272.31
Formula	C₁₇H₁₂N₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	396129-53-6
PubChem ID	447966
InChi Key	IBCXZJCWDGCXQT-UHFFFAOYSA-N
Smiles	N1C=C(C(=N1)C1=CC=CC=N1)C1=CC=NC2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for LY 364947

References are publications that support the biological activity of the product.

Li Dihydropyrrolopyrazole transforming growth factor-β type I receptor kinase domain inhibitors: a novel benzimidazole series with selectivity versus transforming growth factor-β type II receptor kinase and mixed lineage kinase 7. J.Med.Chem. 2006 PMID: 16539403
Shiou Smad4-dependent regulation of urok. plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-β. J.Biol.Chem. 2006 PMID: 16959768
Sawyer Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-μ type I receptor kinase domain. J.Med.Chem. 2003 PMID: 12954047