LY 344864 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 2451

Potent and selective 5-HT1F agonist
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Key Product Details

Description

Potent and selective 5-HT1F agonist

View all 5-HT1F Receptor Agonists »

Product Description

LY 344864 hydrochloride is a potent, selective 5-HT1F receptor agonist (EC50 = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (Ki values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μM for 5-HT1F, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2B, 5-HT2C, 5-HT2A and 5-HT7 receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration.

Licensing Information

Sold under license from Eli Lilly and Company

Product Specifications

Molecular Weight

387.88

Formula

C21H22N3OF.HCl

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide hydrochloride

CAS Number

1217756-94-9

PubChem ID

56972176

InChI Key

OKUHLSYESBLBCP-PKLMIRHRSA-N

SMILES

Cl[H].CN(C)[C@@H]1CCC2=C(C1)C1=CC(NC(=O)C3=CC=C(F)C=C3)=CC=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 19.39 50
DMSO 38.79 100

Preparing Stock Solutions for LY 344864 hydrochloride

The following data is based on the product molecular weight 387.88

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.58 mL 12.89 mL 25.78 mL
5 mM 0.52 mL 2.58 mL 5.16 mL
10 mM 0.26 mL 1.29 mL 2.58 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for LY 344864 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LY 344864 hydrochloride

For research use only

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