LY 255283
Tocris Bioscience, part of Bio-Techne | Catalog # 2208
Selective, competitive BLT2 receptor antagonist
Key Product Details
Description
Selective, competitive BLT2 receptor antagonist
Product Description
LY 255283 is a selective, competitive antagonist of BLT2 receptors (IC50 values are ~ 1 and > 10 μM at human recombinant BLT2 and BLT1 receptors respectively). Inhibits LTB4-induced contraction of lung parenchyma (pA2 = 7.2), and reduces LTB4-mediated airway obstruction in guinea pigs following i.v. and oral administration. .Product Specifications
Molecular Weight
360.46
Formula
C19H28N4O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]ethanone
CAS Number
117690-79-6
PubChem ID
122023
InChI Key
WCGXJPFHTHQNJL-UHFFFAOYSA-N
SMILES
CCC1=C(OCCCCCC(C)(C)C2=NN=NN2)C=C(O)C(=C1)C(C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.05 | 100 | |
| Ethanol | 9.01 | 25 |
Preparing Stock Solutions
for LY 255283
The following data is based on the product molecular weight 360.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.77 mL | 13.87 mL | 27.74 mL |
| 5 mM | 0.55 mL | 2.77 mL | 5.55 mL |
| 10 mM | 0.28 mL | 1.39 mL | 2.77 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Silbaugh Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist. Eur.J.Pharmacol. 1992 PMID: 1335877
- Yokomizo Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J.Biol.Chem. 2001 PMID: 11278893
- Herron Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones. J.Med.Chem. 1992 PMID: 1316967
Product Specific Notices for LY 255283
For research use only
Loading...
Loading...