LY 2119620

Tocris Bioscience, part of Bio-Techne | Catalog # 6964

Positive allosteric modulator of M2 and M4 receptors
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Key Product Details

Description

Positive allosteric modulator of M2 and M4 receptors

View all mAChR M2 Receptor Modulators »

Product Description

LY 2119620 is a positive allosteric modulator of M2 and M4 muscarinic receptors. Potentiates activity of agonist at receptor in G protein-coupled functional assay. Cooperativity factor, α = 19.5 and 79.4 for M2 and M4 in presence of ACh, respectively. Binds in extracellular site.

Product Specifications

Molecular Weight

437.94

Formula

C19H24ClN5O3S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-Amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide

CAS Number

886047-22-9

PubChem ID

57664406

InChI Key

TYTGOXSAAQWLPJ-UHFFFAOYSA-N

SMILES

CN1CCN(CC1)C(=O)COC1=C(Cl)C(C)=C2C(N)=C(SC2=N1)C(=O)NC1CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 43.79 100
DMSO 43.79 100

Preparing Stock Solutions for LY 2119620

The following data is based on the product molecular weight 437.94

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.42 mL 22.83 mL
5 mM 0.46 mL 2.28 mL 4.57 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for LY 2119620

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LY 2119620

For research use only

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