LW 6
Tocris Bioscience, part of Bio-Techne | Catalog # 6322
Malate dehydrogenase-2 (MDH2) inhibitor; also inhibits HIF-1α
Key Product Details
Description
Malate dehydrogenase-2 (MDH2) inhibitor; also inhibits HIF-1α
Alternative Names
CAY 10585
Product Description
LW 6 is a malate dehydrogenase-2 (MDH2) inhibitor (IC50 = 6.3 μM). Also inhibits HIF-1α. Prevents accumulation of HIF-1α in Hep3B cells under hypoxic conditions (IC50 = 2.6 μM) with resulting decrease in expression of HIF-1α target genes VEGF and EPO. Inhibits proliferation of activated human T cells ex vivo.Product Specifications
Molecular Weight
435.51
Formula
C26H29NO5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
Methyl 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]amino]benzoate
CAS Number
934593-90-5
PubChem ID
16124726
InChI Key
BJRPPNOJYFZSLY-QXRPDJHGSA-N
SMILES
O=C(C1=CC=C(C(NC(COC2=CC=C(C3(C[C@H](C4)C5)C[C@H]5C[C@H]4C3)C=C2)=O)=C1)O)OC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.78 | 50 |
Preparing Stock Solutions
for LW 6
The following data is based on the product molecular weight 435.51
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.59 mL | 22.96 mL | 45.92 mL |
| 2.5 mM | 0.92 mL | 4.59 mL | 9.18 mL |
| 5 mM | 0.46 mL | 2.30 mL | 4.59 mL |
| 25 mM | 0.09 mL | 0.46 mL | 0.92 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lee (Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors. J.Med.Chem. 2007 PMID: 17328532
- Ban A novel malate dehydrogenase 2 inhibitor suppresses hypoxia-inducible factor-1 by regulating mitochondrial respiration. PLoS One 2016 PMID: 27611801
- Eleftheriadis Malate dehydrogenase-2 inhibitor LW6 promotes metabolic adaptations and reduces proliferation and apoptosis in activated human T-cells. Exp.Ther.Med. 2015 PMID: 26640580
Product Specific Notices for LW 6
For research use only
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