Key Product Details
Description: | Competitive melatonin MT1/MT2 antagonist |
Chemical Name: | N-Acetyl-2-benzyltryptamine |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 292.38 |
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Citations for Luzindole (16)
Citations are publications that use Bio-Techne products. Selected citations for Luzindole include:
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Hou et al.
(2017)
Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats.
Front Cell Neurosci.
11:98
PMID: 28473754 -
Letra-Vilela et al.
(2016)
Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin
Molecular and Cellular Endocrinology.
434:238
PMID: 27402602 -
Cecon et al.
(2015)
Amyloid β peptide directly impairs pineal gland melatonin synthesis and melatonin receptor signaling through the ERK pathway.
FASEB J.
29:2566
PMID: 25757565 -
Legros et al.
(2014)
Melatonin MT1 and MT2 receptors display different molecular pharmacologies only in the G-protein coupled state.
Br J Pharmacol.
171:186
PMID: 24117008 -
Nishiyama and Hirai
(2014)
The melatonin agonist rame. induces duration-dependent clock gene expression through cAMP signaling in pancreatic INS-1 β-cells.
PLoS One.
9:e102073
PMID: 25013953 -
Chen et al.
(2014)
Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain.
J Clin Invest.
20:1298
PMID: 24574803 -
Muxel et al.
(2013)
NF-κB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene.
Endocrinology.
7:e52010
PMID: 23284853 -
Baba et al.
(2013)
Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function.
Sci Signal.
6:ra89
PMID: 24106342 -
Faria et al.
(2013)
Melatonin acts through MT1/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats.
Am J Physiol Endocrinol Metab.
305:E230
PMID: 23695212 -
Kojima et al.
(2011)
Melatonin inhibits tachykinin NK2 receptor-triggered 5-HT release from guinea pig isolated colonic mucosa.
Br J Pharmacol.
162:1179
PMID: 21091649 -
Tunstall et al.
(2011)
MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries.
J Neuroinflammation.
336:127
PMID: 20959363 -
Mickle et al.
(2010)
Antinociceptive effects of melatonin in a rat model of post-inflammatory visceral hyperalgesia: a centrally mediated process.
Pain.
149:555
PMID: 20413219 -
Silva et al.
(2007)
Melatonin inhibits nitric oxide production by microvascular endothelial cells in vivo and in vitro.
Br J Pharmacol.
151:195
PMID: 17375079 -
Savinainen et al.
(2005)
Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor.
Br J Pharmacol.
145:636
PMID: 15852035 -
Roy et al.
(2001)
Cyclical regulation of GnRH gene expression in GT1-7 GnRH-Secr.g neurons by melatonin.
World J Gastroenterol.
142:4711
PMID: 11606436 -
Sjöblom et al.
(2001)
Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion.
J Pharmacol Exp Ther.
108:625
PMID: 11518737
There are no citations that match your criteria.
Customer Reviews for Luzindole (1)
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Species: HumanAssay Type: In VitroCell Line/Tissue: HepG2, and Huh,It is a good MT1/MT2 agonist. Can activate cAMP and its downstream targets. Used at 10 uM concentration
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