LUF 5834
Tocris Bioscience, part of Bio-Techne | Catalog # 4603
Potent adenosine A2A and A2B receptor partial agonist
Key Product Details
Description
Potent adenosine A2A and A2B receptor partial agonist
Product Description
LUF 5834 is a potent A2A and A2B adenosine receptor partial agonist (Ki = 2.6 nM and EC50 = 12 nM respectively). Also exhibits selectivity for A1 over A3 (Ki values are 2.6 and 538 nM respectively).Product Specifications
Molecular Weight
348.38
Formula
C17H12N6OS
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-Amino-4-(4-hydroxyphenyl)-6-[(1H-imidazol-2-ylmethyl)thio]-3,5-pyridinecarbonitrile
CAS Number
333962-91-7
PubChem ID
1150683
InChI Key
WLBUICQBNZXIDJ-UHFFFAOYSA-N
SMILES
NC1=NC(SCC3=NC=CN3)=C(C#N)C(C2=CC=C(O)C=C2)=C1C#N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.84 | 100 |
Preparing Stock Solutions
for LUF 5834
The following data is based on the product molecular weight 348.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.87 mL | 14.35 mL | 28.70 mL |
| 5 mM | 0.57 mL | 2.87 mL | 5.74 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.87 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lane A novel nonribose agonist, LUF5834, engages residues that are distinct from those of adenosine-like ligands to activate the adenosine A2a receptor Mol.Pharmacol. 2012 PMID: 22188926
- Beukers New, non-adenosine, high potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine J.Med.Chem 2004 PMID: 15239649
Product Specific Notices for LUF 5834
For research use only
Loading...
Loading...