LUF 5834

Name: LUF 5834
Brand: Tocris Bioscience
SKU: 4603

Tocris Bioscience, part of Bio-Techne | Catalog # 4603

Citations (11)

COA / SDS

Potent adenosine A2A and A2B receptor partial agonist

Key Product Details

Description:	Potent adenosine A_2A and A_2B receptor partial agonist
Chemical Name:	2-Amino-4-(4-hydroxyphenyl)-6-[(1H-imidazol-2-ylmethyl)thio]-3,5-pyridinecarbonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	348.38

View Full Technical Details for LUF 5834

Technical Data
Citations

Biological Activity for LUF 5834

LUF 5834 is a potent A_2A and A_2B adenosine receptor partial agonist (K_i = 2.6 nM and EC₅₀ = 12 nM respectively). Also exhibits selectivity for A₁ over A₃ (K_i values are 2.6 and 538 nM respectively).

Compound Libraries for LUF 5834

LUF 5834 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for LUF 5834

M. Wt	348.38
Formula	C₁₇H₁₂N₆OS
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	333962-91-7
PubChem ID	1150683
InChi Key	WLBUICQBNZXIDJ-UHFFFAOYSA-N
Smiles	NC1=NC(SCC3=NC=CN3)=C(C#N)C(C2=CC=C(O)C=C2)=C1C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LUF 5834

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	34.84	100

Preparing Stock Solutions for LUF 5834

The following data is based on the product molecular weight 348.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.87 mL	14.35 mL	28.70 mL
5 mM	0.57 mL	2.87 mL	5.74 mL
10 mM	0.29 mL	1.44 mL	2.87 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

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References for LUF 5834

References are publications that support the biological activity of the product.

Lane A novel nonribose agonist, LUF5834, engages residues that are distinct from those of adenosine-like ligands to activate the adenosine A_2a receptor Mol.Pharmacol. 2012 PMID: 22188926
Beukers New, non-adenosine, high potency agonists for the human adenosine A_2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine J.Med.Chem 2004 PMID: 15239649