LU AA33810

Name: LU AA33810
Brand: Tocris Bioscience
SKU: 3562

Tocris Bioscience, part of Bio-Techne | Catalog # 3562

Citations (2)

COA / SDS

Potent NPY Y5 receptor antagonist

Key Product Details

Description:	Potent NPY Y₅ receptor antagonist
Chemical Name:	N-[[trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]methanesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	423.62

View Full Technical Details for LU AA33810

Technical Data
Citations

Biological Activity for LU AA33810

LU AA33810 is a potent neuropeptide Y (NPY) Y₅ receptor antagonist (K_i = 1.5 nM in vitro). Displays ≥ 3300-fold affinity for Y₅ over Y₁, Y₂ and Y₄ receptors. Also binds human 5-HT_2B and 5-HT_1A receptors (K_i values are 247 and 478 nM respectively). Exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity.

Compound Libraries for LU AA33810

LU AA33810 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for LU AA33810

M. Wt	423.62
Formula	C₁₉H₂₅N₃O₂S₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	304008-29-5
PubChem ID	22254068
InChi Key	UWSBTSAJZMIHBL-UHFFFAOYSA-N
Smiles	O=S(NC[C@H](CC4)CC[C@@H]4NC1=NC(C2=CC=CC=C2SCC3)=C3S1)(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LU AA33810

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.36	100

Preparing Stock Solutions for LU AA33810

The following data is based on the product molecular weight 423.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.36 mL	11.80 mL	23.61 mL
5 mM	0.47 mL	2.36 mL	4.72 mL
10 mM	0.24 mL	1.18 mL	2.36 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

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References for LU AA33810

References are publications that support the biological activity of the product.

Walker The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects J.Pharmacol.Exp.Ther. 2009 PMID: 19098165