LTGO-33 New
Tocris Bioscience, part of Bio-Techne | Catalog # 8865
Potent and selective state-independent inhibitor of NaV1.8 sodium channels
Key Product Details
Description
Potent and selective state-independent inhibitor of NaV1.8 sodium channels
Product Description
LTGO-33 is a potent and selective state-independent inhibitor of NaV1.8 sodium channels (IC50 = 13 nM for the closed state; IC50 = 24 nM for the inactive state). It displays 600-fold selectivity over other sodium channels such as NaV1.1-1.7 and NaV1.9. By binding to NaV1.8 channels, LTGO-33 inhibits action potential initiation and transmission of pain signals in human DRG neurons. Unlike other NaV1.8 inhibitors that preferentially interact with an inactivated state via the pore region, LTGO-33 is state-independent with similar potencies against closed and inactivated channels.Licensing Information
Sold with kind permission of Latigo BiotherapeuticsProduct Specifications
Molecular Weight
467.44
Formula
C21H17F4N3O3S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(R)-2-(4-Fluoro-2-methylphenoxy)-N-(3-(S-methylsulfonimidoyl)phenyl)-5-(trifluoromethyl)nicotinamide
CAS Number
2834106-06-6
PubChem ID
169124157
InChI Key
IIJWTXGHWFZLBF-JGCGQSQUSA-N
SMILES
N=[S@](C1=CC=CC(NC(C2=C(N=CC(C(F)(F)F)=C2)OC3=C(C=C(C=C3)F)C)=O)=C1)(C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.74 | 100 | |
| Ethanol | 46.74 | 100 |
Preparing Stock Solutions
for LTGO-33
The following data is based on the product molecular weight 467.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.14 mL | 10.70 mL | 21.39 mL |
| 5 mM | 0.43 mL | 2.14 mL | 4.28 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.14 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gilchrist Pharmacologic characterization of LTGO-33, a selective small molecule inhibitor of the voltage-gated sodium channel NaV1.8 with a unique mechanism of action. Mol.Pharmacol 2024 PMID: 38195157
Product Specific Notices for LTGO-33
For research use only
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