LRRK2-IN-1
Tocris Bioscience, part of Bio-Techne | Catalog # 4273
Potent and selective LRRK2 inhibitor
Product Description
LRRK2-IN-1 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2). Inhibits both G2019S mutant and wild-type LRRK2 kinase activity (IC50 values are 6 and 13 nM respectively). Causes dephosphorylation, ubiquitination and degradation of LRRK2. Inhibits IFN-γ-induced monocyte maturation in vitro.Licensing Information
Sold under license from the Dana-Farber Cancer Institute.Product Specifications
Molecular Weight
570.69
Formula
C31H38N8O3
Storage
Store at -20°C
Purity
≥98%
Chemical Name
5,11-Dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
CAS Number
1234480-84-2
PubChem ID
46843906
InChI Key
IWMCPJZTADUIFX-UHFFFAOYSA-N
SMILES
O=C2C3=C(C=CC=C3)N(C)C1=NC(NC4=C(OC)C=C(C(N5CCC(N6CCN(C)CC6)CC5)=O)C=C4)=NC=C1N2C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 57.01 | 100 |
Preparing Stock Solutions
for LRRK2-IN-1
The following data is based on the product molecular weight 570.69
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.75 mL | 8.76 mL | 17.52 mL |
| 5 mM | 0.35 mL | 1.75 mL | 3.50 mL |
| 10 mM | 0.18 mL | 0.88 mL | 1.75 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.35 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhao LRRK2 Dephosphorylation increases its ubiquitination. Biochem.J. 2015 PMID: 25939886
- Thévenet Regulation of LRRK2 expression points to a functional role in human monocyte maturation. PLoS One 2011 PMID: 21738687
- Deng Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nat.Chem.Biol. 2011 PMID: 21378983
Product Specific Notices for LRRK2-IN-1
For research use only
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