Loxiglumide
Tocris Bioscience, part of Bio-Techne | Catalog # 3036
CCK1 antagonist; active in vivo
Key Product Details
Description
CCK1 antagonist; active in vivo
Alternative Names
CR 1505
Product Description
Loxiglumide is a CCK1 antagonist. Suppresses CCK-induced proliferation of acinar cells. Inhibits pancreatic secretion of digestive enzymes. Active in vivo.Product Specifications
Molecular Weight
461.38
Formula
C21H30Cl2N2O5
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
4-[(3,4-Dichlorobenzoyl)amino]-5-[(3-methoxypropyl)pentylamino]-5-oxopentanoic acid
CAS Number
107097-80-3
PubChem ID
60182
InChI Key
QNQZBKQEIFTHFZ-UHFFFAOYSA-N
SMILES
O=C(NC(CCC(O)=O)C(N(CCCOC)CCCCC)=O)C1=CC=C(Cl)C(Cl)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.14 | 100 | |
| Ethanol | 46.14 | 100 |
Preparing Stock Solutions
for Loxiglumide
The following data is based on the product molecular weight 461.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.17 mL | 10.84 mL | 21.67 mL |
| 5 mM | 0.43 mL | 2.17 mL | 4.33 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.17 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kanemitsu Effects of the cholecystokinin A receptor antagonist loxiglumide on the proliferation and cell cycle time of pancreatic acinar cells in rats. Pancreas 2006 PMID: 16552340
- Nakano S Effect of the cholecystokinin receptor antagonist loxiglumide on pancreatic exocrine function in rats after acute pancreatitis. Pancreas 1995 PMID: 7542770
- Makovec New glutamic and aspartic derivatives with potent CCK-antagonistic activity. Eur. J. Med.Chem.
Product Specific Notices for Loxiglumide
For research use only
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