Loratidine

Name: Loratidine
Brand: Tocris Bioscience
SKU: 1944

Tocris Bioscience, part of Bio-Techne | Catalog # 1944

Citations (7)

COA / SDS

Peripheral H1 antagonist; antiallergic agent

Discontinued Product

1944 has been discontinued. View all Histamine H1 Receptor Antagonists products.

Key Product Details

Description:	Peripheral H₁ antagonist; antiallergic agent
Alternative Names:	SCH 29851
Chemical Name:	4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester
Purity:	≥99% (HPLC)
Molecular Weight:	382.88

View Full Technical Details for Loratidine

Technical Data
Citations

Biological Activity for Loratidine

Loratidine is a peripheral histamine H₁ receptor antagonist (K_i = 35 nM); devoid of central effects. Orally active antiallergic agent.

Compound Libraries for Loratidine

Loratidine is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Loratidine

M. Wt	382.88
Formula	C₂₂H₂₃ClN₂O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	79794-75-5
PubChem ID	3957
InChi Key	JCCNYMKQOSZNPW-UHFFFAOYSA-N
Smiles	CCOC(=O)N1CC\C(CC1)=C1/C2=NC=CC=C2CCC2=C1C=CC(Cl)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Loratidine

References are publications that support the biological activity of the product.

Barnett Evaluation of the CNS properties of SCH 29851, a potential non-sedating antihistamine. Agents Actions 1984 PMID: 6236679
Kreutner Antiallergic activity of loratidine, a non-sedating antihistamine. Allergy 1987 PMID: 2436504
Ahn and Barnett Selective displacement of [³H]mepyramine from peripheral vs. central nervous system receptors by loratadine, a non-sedating antihistamine. Eur.J.Pharmacol. 1986 PMID: 2875889