LMK 235

Name: LMK 235
Brand: Tocris Bioscience
SKU: 4830

Tocris Bioscience a Bio-Techne Brand

Catalog # 4830

Citations (2)

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Key Product Details

Description:	Selective HDAC4/HDAC5 inhibitor
Chemical Name:	N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethylbenzamide
Purity:	≥98% (HPLC)
Molecular Weight:	294.35

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Biological Activity for LMK 235

LMK 235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor (IC₅₀ values are 4.22, 11.9, 55.7, 320, 852, 881, and 1278 nM for HDAC 5, 4, 6, 1, 11, 2, and 8, respectively). Demonstrates activity against chemoresistant cancer cell lines in an MTT assay for cytotoxicity using human ovarian cancer cell lines A2780 and cisplatin resistant A2780CisR (IC₅₀ = 0.49 and 0.32 μM respectively).

Compound Libraries for LMK 235

LMK 235 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for LMK 235

M. Wt	294.35
Formula	C₁₅H₂₂N₂O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1418033-25-6
PubChem ID	71520717
InChi Key	VRYZCEONIWEUAV-UHFFFAOYSA-N
Smiles	CC1=CC(C(NOCCCCCC(NO)=O)=O)=CC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LMK 235

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.43	100
	ethanol	29.43	100

Preparing Stock Solutions for LMK 235

The following data is based on the product molecular weight 294.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.40 mL	16.99 mL	33.97 mL
5 mM	0.68 mL	3.40 mL	6.79 mL
10 mM	0.34 mL	1.70 mL	3.40 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

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References for LMK 235

References are publications that support the biological activity of the product.

Marek Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. J.Med.Chem. 2013 PMID: 23252603

Citations for LMK 235 (2)

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Citations are publications that use Bio-Techne products. Selected citations for LMK 235 include:

Lu et al. (2019) Histone deacetylase 4 promotes type I IF. signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6. Proc Natl Acad Sci U S A. 2019;
PMID: 31127039
Chen et al. (2015) AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol. Cell Cycle. 14:2520
PMID: 26061431

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