LIMKi 3

Tocris Bioscience, part of Bio-Techne | Catalog # 4745

Potent LIM kinase inhibitor; antitumor
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Key Product Details

Description

Potent LIM kinase inhibitor; antitumor

Alternative Names

BMS 5

View all LIMK Inhibitors »

Product Description

LIMKi 3 is a potent LIM kinase inhibitor (IC50 values are 7 and 8 nM for LIMK1 and LIMK2 respectively). Inhibits cofilin phosphorylation in MDA-MB-231 breast cancer cells. Reduces MDA-MB-231 tumor cell invasion in a 3D matrigel invasion assay.

Product Specifications

Molecular Weight

431.29

Formula

C17H14Cl2F2N4OS

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methylpropanamide

CAS Number

1338247-35-0

PubChem ID

56965901

InChI Key

IVUGBSGLHRJSSP-UHFFFAOYSA-N

SMILES

FC(F)C1=NN(C2=C(Cl)C=CC=C2Cl)C(C3=CN=C(NC(C(C)C)=O)S3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.13 100

Preparing Stock Solutions for LIMKi 3

The following data is based on the product molecular weight 431.29

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.59 mL 23.19 mL
5 mM 0.46 mL 2.32 mL 4.64 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for LIMKi 3

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LIMKi 3

For research use only

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