LIH 383
Tocris Bioscience, part of Bio-Techne | Catalog # 8095
Atypical chemokine receptor (ACKR3) agonist
Key Product Details
Description
Atypical chemokine receptor (ACKR3) agonist
Product Description
LIH 383 is a potent and highly selective atypical chemokine receptor (ACKR3/CXCR7) agonist. LIH 383 competes directly with CXCL12-AF647 and is more potent in inducing β-arrestin recruitment to ACKR3 (EC50 = 0.61 nM) than the full-length chemokine ligands CXCL12 or CXCL11 (EC50 values are 1.2 nM and 2.2 nM, respectively). In a rat ex vivo model, LIH 383 increases the availability and signaling of opioid peptides at classical receptors.Licensing Information
Sold under patent license from Luxembourg Institute of Health.Product Specifications
Molecular Weight
997.23
Formula
C45H72N16O8S
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
2866266-58-0
InChI Key
HKVZPBVWPFDBBQ-LBBUGJAGSA-N
SMILES
O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=CC=C2)N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 2mg/ml in water |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kleist Conformational selection guides β-arrestin recruitment at a biased G protein-coupled receptor. Science 2022 PMID: 35857540
- Meyrath The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides. Nat.Commun. 2020 PMID: 32561830
Product Specific Notices for LIH 383
For research use only
Loading...
Loading...