Lidocaine

Name: Lidocaine
Brand: Tocris Bioscience
SKU: 3057
Rating: 5 (1 reviews)

Catalog # 3057 | Tocris Bioscience a Bio-Techne Brand

(1)

Citations (2)

COA / SDS

Na+ channel blocker

Key Product Details

Description:	Na⁺ channel blocker
Chemical Name:	2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
Purity:	≥99% (HPLC)
Molecular Weight:	234.34

View Full Technical Details for Lidocaine

Technical Data
Citations (2) / Reviews (1)

Biological Activity for Lidocaine

Lidocaine is an anasthetic and class Ib antiarrhythmic agent. Blocks voltage-gated sodium channels in the inactivated state.

Technical Data for Lidocaine

M. Wt	234.34
Formula	C₁₄H₂₂N₂O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	137-58-6
PubChem ID	3676
InChi Key	NNJVILVZKWQKPM-UHFFFAOYSA-N
Smiles	O=C(CN(CC)CC)NC1=C(C)C=CC=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Lidocaine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	23.43	100
	ethanol	23.43	100

Preparing Stock Solutions for Lidocaine

The following data is based on the product molecular weight 234.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.27 mL	21.34 mL	42.67 mL
5 mM	0.85 mL	4.27 mL	8.53 mL
10 mM	0.43 mL	2.13 mL	4.27 mL
50 mM	0.09 mL	0.43 mL	0.85 mL

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Reconstitution Calculator

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References for Lidocaine

References are publications that support the biological activity of the product.

Sarraf Tedisamil and lidocaine enhance each other's antiarrhythmic activity against ischaemia-induced arrhythmias in rats. Br.J.Pharmacol. 2003 PMID: 12922925

Citations for Lidocaine (2)

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Citations are publications that use Bio-Techne products. Selected citations for Lidocaine include:

Hernández-Cascales (2017) Resveratrol enhances the inotropic effect but inhibits the proarrhythmic effect of sympathomimetic agents in rat myocardium. PeerJ. 5:e3113
PMID: 28382232
Miguel Angel Garcia-Bereguiain et al. (2016) Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo The Journal of Neuroscience. 6:7268
PMID: 27383600

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Customer Reviews for Lidocaine (1)

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Lidocaine in prelimbic medial prefrontal cortex blocks cue-induced reinstatement of MDMA seeking

Name: Kevin Ball

Species: Rat

Assay Type: In Vivo

Bilateral microinjections of lidocaine (100 micrograms/0.5 microliter/side) into prelimbic, but not infralimbic, medial prefrontal cortex blocked cue-induced reinstatement of MDMA (ecstasy)-seeking behavior compared with saline microinjections into the same region. Lidocaine microinjections into either region did not, however, have an effect on food-maintained responding, ruling out a nonspecific disruption of motor performance.

PMID: 4078904 Reference

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