Licarbazepine

Name: Licarbazepine
Brand: Tocris Bioscience
SKU: 3865
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3865

(1)

Citations (2)

COA / SDS

Active metabolite of oxcarbazepine (Cat. No. 3864)

Key Product Details

Description:	Active metabolite of oxcarbazepine (Cat. No. 3864)
Alternative Names:	GP 47779
Chemical Name:	10,11-Dihydro-10-hydroxy-5H-dibenz(Z)[b,f]azepin-5-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	254.28

View Full Technical Details for Licarbazepine

Technical Data
Citations / Reviews (1)

Biological Activity for Licarbazepine

Licarbazepine is an active metabolite of oxcarbazepine (Cat. No. 3864). Produces dose-dependent inhibition of glutamatergic excitatory postsynaptic potentials (EPSPs). Displays anticonvulsant activity; exhibits minor potentiation of GABA_A receptor currents.

Compound Libraries for Licarbazepine

Licarbazepine is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Licarbazepine

M. Wt	254.28
Formula	C₁₅H₁₄N₂O₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	29331-92-8
PubChem ID	114709
InChi Key	BMPDWHIDQYTSHX-UHFFFAOYSA-N
Smiles	NC(N2C1=CC=CC=C1C(O)CC3=C2C=CC=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Licarbazepine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	25.43	100

Preparing Stock Solutions for Licarbazepine

The following data is based on the product molecular weight 254.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.93 mL	19.66 mL	39.33 mL
5 mM	0.79 mL	3.93 mL	7.87 mL
10 mM	0.39 mL	1.97 mL	3.93 mL
50 mM	0.08 mL	0.39 mL	0.79 mL

Molarity Calculator

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Reconstitution Calculator

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References for Licarbazepine

References are publications that support the biological activity of the product.

Benes Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives. J.Med.Chem. 1999 PMID: 10411478
Zheng Oxcarbazepine, not its active metabolite, potentiates GABA_A activation and aggravates absence seizures. Epilepsia 2009 PMID: 18717705
Calabresi Action of GP 47779, the active metabolite of oxcarbazepine, on the corticostriatal system. I. Modulation of corticostriatal synaptic transmission. Epilepsia 1995 PMID: 7555963