LG 100268

Name: LG 100268
Brand: Tocris Bioscience
SKU: 5920

Tocris Bioscience, part of Bio-Techne | Catalog # 5920

COA / SDS

Potent and selective RXR agonist; also activates RXR/PPARγ heterodimers

Key Product Details

Description:	Potent and selective RXR agonist; also activates RXR/PPARγ heterodimers
Chemical Name:	6-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)cyclopropyl]-3-pyridinecarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	363.49

View Full Technical Details for LG 100268

Technical Data
Citations

Biological Activity for LG 100268

LG 100268 is a potent and selective retinoid X receptor (RXR) agonist (EC₅₀ = 4 nM). Displays >1000-fold selectivity for RXR over RAR. Activates RXR homodimers to induce transcriptional activation. Induces tissue transglutaminase (TGase) activity in HL-60 human promyelocytic leukemia cell line. Also activates RXR/PPARγ heterodimers.

Compound Libraries for LG 100268

LG 100268 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for LG 100268

M. Wt	363.49
Formula	C₂₄H₂₉NO₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	153559-76-3
PubChem ID	3922
InChi Key	SLXTWXQUEZSSTJ-UHFFFAOYSA-N
Smiles	CC1=C(C2(C3=CC=C(C(O)=O)C=N3)CC2)C=C4C(C(C)(CCC4(C)C)C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LG 100268

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	18.17	50

Preparing Stock Solutions for LG 100268

The following data is based on the product molecular weight 363.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.50 mL	27.51 mL	55.02 mL
2.5 mM	1.10 mL	5.50 mL	11.00 mL
5 mM	0.55 mL	2.75 mL	5.50 mL
25 mM	0.11 mL	0.55 mL	1.10 mL

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References for LG 100268

References are publications that support the biological activity of the product.

Boehm Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells. J.Med.Chem. 1995 PMID: 7636877
Lala Activation of specific RXR heterodimers by an antagonist of RXR homodimers. Nature. 1996 PMID: 8837780