Leupeptin hemisulfate

Name: Leupeptin hemisulfate
Brand: Tocris Bioscience
SKU: 1167
Rating: 4 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 1167

Citations (2)

(1)

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Key Product Details

Description:	Inhibits trypsin-like/cysteine proteases
Purity:	≥95% (HPLC)
Molecular Weight:	475.6

View Full Technical Details for Leupeptin hemisulfate

Biological Activity for Leupeptin hemisulfate

Leupeptin hemisulfate is a reversible inhibitor of trypsin-like and cysteine proteases such as calpain. Shown to inhibit activation-induced programmed cell death.

Technical Data for Leupeptin hemisulfate

M. Wt	475.6
Formula	C₂₀H₃₈N₆O₄.½H₂SO₄
Single Letter Sequence	LLR (Modifications: Leu-1 = N-terminal Ac, Arg-3 = Arginal)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	103476-89-7
PubChem ID	2733491
InChi Key	CIPMKIHUGVGQTG-VFFZMTJFSA-N
Smiles	OS(O)(=O)=O.[H]C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O.[H]C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Leupeptin hemisulfate

Solubility

Soluble to 10mg/ml in water

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References for Leupeptin hemisulfate

References are publications that support the biological activity of the product.

Sarin Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors. J.Immunol. 1994 PMID: 8021517
Mehdi Cell-penetrating inhibitors of calpain. TiBS 1991 PMID: 1877091
Wang Developing selective inhibitors of calpain. TiPS 1990 PMID: 2185586

Citations for Leupeptin hemisulfate (2)

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Citations are publications that use Bio-Techne products. Selected citations for Leupeptin hemisulfate include:

Berg et al. (2019) Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation. Cell Rep. 27:2837
PMID: 31167131
Haller et al. (2015) Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. J Pharmacol Exp Ther. 10:2269
PMID: 25629932

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Customer Reviews for Leupeptin hemisulfate (1)

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Happy with results

Name: Estela Correa

Species: Mouse

Assay Type: Ex Vivo

I used it as a protease inhibitor. Concentration of 1:1000.

Be careful when measuring weight. Very light material.

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Product Documents for Leupeptin hemisulfate

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.