Leukotriene B₄

Name: Leukotriene B 4
Brand: tocris
SKU: 2307

Catalog # 2307

Citations (1)

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Key Product Details

Description:	BLT₁/BLT₂ receptor agonist and potent chemotactic factor
Alternative Names:	LTB₄, 5,12-DiHETE
Chemical Name:	(5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid
Molecular Weight:	336.47

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Biological Activity

Leukotriene B₄ is a potent lipid inflammatory mediator derived from the 5-lipoxygenase pathway of arachidonic acid metabolism. Binds to BLT₁ and BLT₂ receptors and acts as a potent chemotactic agent and activator of leukocytes. Also displays antiviral activity towards DNA viruses and retroviruses.

Technical Data

M. Wt	336.47
Formula	C₂₀H₃₂O₄
Storage	Store at -20°C
CAS Number	71160-24-2
PubChem ID	5280492
InChi Key	VNYSSYRCGWBHLG-AMOLWHMGSA-N
Smiles	O[C@@H](CCCC(O)=O)\C=C/C=C/C=C/[C@H](O)C/C=C\CCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 50µg/ml)

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References

References are publications that support the biological activity of the product.

Bray Leukotriene B4: an inflammatory mediator in vivo. Prostaglandins 1981 PMID: 6270742
Ford-Hutchinson Leukotriene B4 in inflammation. Crit.Rev.Immunol. 1990 PMID: 2155000
Yokomitso Leukotriene B₄: metabolism and signal transduction. Arch.Biochem.Biophys. 2001 PMID: 11368003

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for Leukotriene B₄ include:

Fernandes et al. (2013) Superoxide generation and leukocyte accumulation: key elements in the mediation of leukotriene B4-induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1. FASEB J. 27:1664
PMID: 23271050

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Product Documents

COA

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Leukotriene B₄

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Leukotriene B4

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Key Product Details

Complete Your Research

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Biological Activity

Technical Data

Solubility

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations (1)

Product Documents

COA

Certificate of Analysis

SDS

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Leukotriene B₄