Letrozole

Tocris Bioscience, part of Bio-Techne | Catalog # 4382

Potent, reversible non-steroidal aromatase inhibitor
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Key Product Details

Description

Potent, reversible non-steroidal aromatase inhibitor

Alternative Names

CGS 20267

View all Cytochrome P450 Inhibitors »

Product Description

Letrozole is a potent, reversible non-steroidal aromatase inhibitor (IC50 = 11.5 nM). Displays antitumor effects in several animal models. Suppresses the endogenous aromatase-induced proliferation of MCF-7 cells.

Product Specifications

Molecular Weight

285.30

Formula

C17H11N5

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4,4'-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile

CAS Number

112809-51-5

PubChem ID

3902

InChI Key

HPJKCIUCZWXJDR-UHFFFAOYSA-N

SMILES

N#CC(C=C2)=CC=C2C(N3N=CN=C3)C1=CC=C(C#N)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.53 100

Preparing Stock Solutions for Letrozole

The following data is based on the product molecular weight 285.30

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.51 mL 17.53 mL 35.05 mL
5 mM 0.70 mL 3.51 mL 7.01 mL
10 mM 0.35 mL 1.75 mL 3.51 mL
50 mM 0.07 mL 0.35 mL 0.70 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for Letrozole

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Letrozole

For research use only

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