Letrozole

Name: Letrozole
Brand: Tocris Bioscience
SKU: 4382

Tocris Bioscience, part of Bio-Techne | Catalog # 4382

Citations (28)

COA / SDS

Potent, reversible non-steroidal aromatase inhibitor

Key Product Details

Description:	Potent, reversible non-steroidal aromatase inhibitor
Alternative Names:	CGS 20267
Chemical Name:	4,4'-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	285.3

View Full Technical Details for Letrozole

Technical Data
Citations

Biological Activity for Letrozole

Letrozole is a potent, reversible non-steroidal aromatase inhibitor (IC₅₀ = 11.5 nM). Displays antitumor effects in several animal models. Suppresses the endogenous aromatase-induced proliferation of MCF-7 cells.

Compound Libraries for Letrozole

Letrozole is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Letrozole

M. Wt	285.3
Formula	C₁₇H₁₁N₅
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	112809-51-5
PubChem ID	3902
InChi Key	HPJKCIUCZWXJDR-UHFFFAOYSA-N
Smiles	N#CC(C=C2)=CC=C2C(N3N=CN=C3)C1=CC=C(C#N)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Letrozole

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	28.53	100

Preparing Stock Solutions for Letrozole

The following data is based on the product molecular weight 285.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.51 mL	17.53 mL	35.05 mL
5 mM	0.70 mL	3.51 mL	7.01 mL
10 mM	0.35 mL	1.75 mL	3.51 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

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Reconstitution Calculator

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References for Letrozole

References are publications that support the biological activity of the product.

Bhatnagar Highly selective inhbition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor. J.Steroid Biochem.Mol.Biol. 1990 PMID: 2149502
Bhatnagar The discovery and mechanism of action of letr. Breast Cancer Res.Treat. 2007 PMID: 17912633
Mitropoulou Letrozole as a potent inhibitor of cell proliferation and expression of metalloproteinases (MMP-2 and MMP-9) by human epithelial breast cancer cells. Int.J.Cancer 2003 PMID: 12569569