Lenalidomide 5'-piperazine-7'-methoxy

Name: Lenalidomide 5'-piperazine-7'-methoxy
Brand: Tocris Bioscience
SKU: 8848

Tocris Bioscience, part of Bio-Techne | Catalog # 8848

COA / SDS

Cereblon ligand with terminal piperazine for onward chemistry

Key Product Details

Description:	Cereblon ligand with terminal piperazine for onward chemistry
Chemical Name:	3-(7-Methoxy-1-oxo-5-(piperazin-1-yl)isoindolin-2-yl)piperidine-2,6-dione hydrochloride
Purity:	≥95% (HPLC)
Molecular Weight:	394.86

View Full Technical Details for Lenalidomide 5'-piperazine-7'-methoxy

Technical Data
Citations

Biological Activity for Lenalidomide 5'-piperazine-7'-methoxy

Lenalidomide 5'-piperazine-7'-methoxy is a functionalized cereblon ligand for PROTAC^® research and development; incorporates an E3 ligase ligand with a terminal piperazine for onward chemistry to generate Protein Degraders with rigid linkers. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for Lenalidomide 5'-piperazine-7'-methoxy

M. Wt	394.86
Formula	C₁₈H₂₂N₄O₄.HCl
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2242743-87-7
PubChem ID	146173390
InChi Key	CDDVRWUWIZZRJK-UHFFFAOYSA-N
Smiles	O=C1N(CC2=CC(N3CCNCC3)=CC(OC)=C12)C4C(NC(CC4)=O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Lenalidomide 5'-piperazine-7'-methoxy

References are publications that support the biological activity of the product.

Bagal Discovery of a series of orally bioavailable androgen receptor degraders for the treatment of prostate cancer. J.Med.Chem. 2024 PMID: 38991141