LCL 161, phenol

Tocris Bioscience, part of Bio-Techne | Catalog # 7178

Functionalized IAP ligand for PROTACs
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Key Product Details

Description

Functionalized IAP ligand for PROTACs

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Product Description

LCL 161, phenol is a functionalized IAP (XIAP and cIAP) ligand for PROTAC® research and development. Boc protected LCL 161. Supplied with a phenol functional handle for ready conjugation to a linker/target protein ligand. NanoBRET assays show EC50 values of 7.5, 18.2 and 25.3 nM for cIAP1, XIAP and cIAP2 proteins, respectively. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications

Molecular Weight

598.76

Formula

C31H42N4O6S

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

tert-Butyl ((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(4-(3-hydroxybenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate

CAS Number

2095244-42-9

InChI Key

SPXBMEKMIPOEMC-LQGLAIQGSA-N

SMILES

OC1=CC(C(C2=CSC([C@@H]3CCCN3C([C@H](C4CCCCC4)NC([C@@H](N(C(OC(C)(C)C)=O)C)C)=O)=O)=N2)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for LCL 161, phenol

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LCL 161, phenol

For research use only

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