LCL 161, phenol

Name: LCL 161, phenol
Brand: Tocris Bioscience
SKU: 7178

Tocris Bioscience, part of Bio-Techne | Catalog # 7178

COA / SDS

Functionalized IAP ligand for PROTACs

Key Product Details

Description:	Functionalized IAP ligand for PROTACs
Chemical Name:	tert-Butyl ((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(4-(3-hydroxybenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate
Purity:	≥95% (HPLC)
Molecular Weight:	598.76

View Full Technical Details for LCL 161, phenol

Technical Data
Citations

Biological Activity for LCL 161, phenol

LCL 161, phenol is a functionalized IAP (XIAP and cIAP) ligand for PROTAC^® research and development. Boc protected LCL 161. Supplied with a phenol functional handle for ready conjugation to a linker/target protein ligand. NanoBRET assays show EC₅₀ values of 7.5, 18.2 and 25.3 nM for cIAP1, XIAP and cIAP2 proteins, respectively. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for LCL 161, phenol

M. Wt	598.76
Formula	C₃₁H₄₂N₄O₆S
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2095244-42-9
InChi Key	SPXBMEKMIPOEMC-LQGLAIQGSA-N
Smiles	OC1=CC(C(C2=CSC([C@@H]3CCCN3C([C@H](C4CCCCC4)NC([C@@H](N(C(OC(C)(C)C)=O)C)C)=O)=O)=N2)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for LCL 161, phenol

References are publications that support the biological activity of the product.

Shimokawa Targeting the allosteric site of oncoprotein BCR-ABL as an alternative strategy for effective target protein degradation. ACS Med.Chem.Lett. 2017 PMID: 29057048
Schwalm A toolbox for the generation of chemical probes for baculovirus IAP repeat containing proteins. Front.Cell.Dev.Biol. 2022 PMID: 35721509
Ohoka In vivo knockdown of pathogenic proteins via specific and nongenetic inhibitor of apoptosis protein (IAP)-dependent protein erasers (SNIPERs). J.Biol.Chem. 2017 PMID: 28154167