Latrunculin A

Name: Latrunculin A
Brand: Tocris Bioscience
SKU: 3973

Tocris Bioscience a Bio-Techne Brand

Catalog # 3973

Citations (19)

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Key Product Details

Description:	Inhibitor of actin assembly and polymerization
Chemical Name:	4-[(1R,4Z,8E,10Z,12S,15R, 17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone
Purity:	≥95% (HPLC)
Molecular Weight:	421.55

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Biological Activity for Latrunculin A

Latrunculin A is a reversible inhibitor of actin assembly; blocks actin adenine nucleotide exchange. Complexes with actin in vitro and interacts with actin monomers only, unlike cytochalasins. Prevents actin repolymerization into filaments and disrupts the actin cytoskeleton.

This product is typically reconstituted in DMSO as a primary solvent.

Technical Data for Latrunculin A

M. Wt	421.55
Formula	C₂₂H₃₁NO₅S
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	76343-93-6
PubChem ID	445420
InChi Key	DDVBPZROPPMBLW-IZGXTMSKSA-N
Smiles	C[C@@H](CC[C@]2([H])C[C@@](C[C@](O)([C@]3([H])CSC(N3)=O)O2)([H])O1)\C=C/C=C/CC/C(C)=C\C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Latrunculin A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.22	10

Preparing Stock Solutions for Latrunculin A

The following data is based on the product molecular weight 421.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.72 mL	118.61 mL	237.22 mL
0.5 mM	4.74 mL	23.72 mL	47.44 mL
1 mM	2.37 mL	11.86 mL	23.72 mL
5 mM	0.47 mL	2.37 mL	4.74 mL

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References for Latrunculin A

References are publications that support the biological activity of the product.

Yarmola Actin-latrunculin A structure and function. J.Biol.Chem. 2000 PMID: 10859320
Morton Latrunculin alters the actin-monomer subunit interface to prevent polymerization. Nat.Cell Biol. 2000 PMID: 10854330
Blasberger On the chemistry of latrunculins A and B. Liebigs.Ann.Chem.

Citations for Latrunculin A (19)

Showing 1 - 10 of 19 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Latrunculin A include:

Tazerart et al. (2020) A spike-timing-dependent plasticity rule for dendritic spines. Nat Commun. 11:4276
PMID: 32848151
Lim et al. (2019) Identification of the kinase STK25 as an upstream activator of LATS signaling. Nat Commun. 10:1547
PMID: 30948712
Lionarons et al. (2019) RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance. Cancer Cell. 36:68
PMID: 31257073
Davies et al. (2018) Cell-intrinsic and -extrinsic mechanisms promote cell-type-specific cytokinetic diversity. Elife. 7
PMID: 30028292
Wisdom et al. (2018) Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments. Nat Commun. 9:4144
PMID: 30297715
Neumann et al. (2018) Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation. Dev Cell. 45:67
PMID: 29634937
Haag et al. (2018) The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea. Cell Rep. 24:2418
PMID: 30157434
Lettau et al. (2018) Mechanistic peculiarities of activation-induced mobilization of cytotoxic effector proteins in human T cells. Int Immunol. 30:215
PMID: 29373679
Hubaud et al. (2017) Excitable Dynamics and Yap-Dependent Mechanical Cues Drive the Segmentation Clock. Cell. 171:668
PMID: 28942924
Oenema et al. (2016) Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices. Oncotarget. 8:e65580
PMID: 23840342
Han et al. (2016) Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation Nature. 539:570
PMID: 27820945
Koopmans et al. (2016) Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction. Sci Rep. 6:30676
PMID: 27468699
Petrosyan et al. (2016) The role of Rab6a and phosphorylation of non-muscle myosin IIA tailpiece in alcohol-induced Golgi disorganization. Sci Rep. 6:31962
PMID: 27535804
Suzuki et al. (2015) Spatiotemporal quantification of subcellular ATP levels in a single HeLa cell during changes in morphology. Neuron. 5:16874
PMID: 26575097
Araki et al. (2015) Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP. PLoS One. 85:173
PMID: 25569349
Arash et al. (2014) Arhgef7 promotes activation of the Hippo pathway core kinase Lats. EMBO J. 33:2997
PMID: 25425573
Saba et al. (2014) Rhinovirus-induced macrophage cytokine expression does not require endocytosis or replication. Am J Respir Cell Mol Biol. 50:974
PMID: 24783958
Dalton and Carroll (2013) Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte. J Cell Sci. 126:2955
PMID: 23659999
Kawashima et al. (2012) Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology. Chem Biol. 19:893
PMID: 22840777

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