Lalistat 2
Tocris Bioscience, part of Bio-Techne | Catalog # 6099
Selective LAL inhibitor
Product Description
Lalistat 2 is a selective lysosomal acid lipase inhibitor (IC50 = 152 nM). Exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein lipase (up to 10 μM).Product Specifications
Molecular Weight
296.39
Formula
C13H20N4O2S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl piperidine-1-carboxylate
CAS Number
1234569-09-5
PubChem ID
46867138
InChI Key
PNYYVHOTXOEBEV-UHFFFAOYSA-N
SMILES
O=C(N1CCCCC1)OC2=NSN=C2N3CCCCC3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.64 | 100 | |
| Ethanol | 29.64 | 100 |
Preparing Stock Solutions
for Lalistat 2
The following data is based on the product molecular weight 296.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.37 mL | 16.87 mL | 33.74 mL |
| 5 mM | 0.67 mL | 3.37 mL | 6.75 mL |
| 10 mM | 0.34 mL | 1.69 mL | 3.37 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.67 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hamilton A new method for the measurement of lysosomal acid lipase in dried blood spots using the inhibitor Lalistat 2. Clin.Chim.Acta. 2012 PMID: 22483793
- Rosenbaum Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J.Med.Chem. 2010 PMID: 20557099
- Rosenbaum Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors. Biochim.Biophys.Acta. 2009 PMID: 19699313
Product Specific Notices for Lalistat 2
For research use only
Loading...
Loading...