L-trans-2,4-PDC

Name: L- trans -2,4-PDC
Brand: Tocris Bioscience
SKU: 0298

Tocris Bioscience a Bio-Techne Brand

Catalog # 0298

Citations (4)

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Key Product Details

Description:	Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor
Alternative Names:	trans-4-Carboxy-L-proline
Chemical Name:	L-trans-Pyrrolidine-2,4-dicarboxylic acid
Purity:	≥97% (HPLC)
Molecular Weight:	159.14

View Full Technical Details for L-trans-2,4-PDC

Biological Activity for L-trans-2,4-PDC

L-trans-2,4-PDC is a potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor.

Technical Data for L-trans-2,4-PDC

M. Wt	159.14
Formula	C₆H₉NO₄
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	64769-66-0
PubChem ID	1515192
InChi Key	NRSBQSJHFYZIPH-DMTCNVIQSA-N
Smiles	O=[C@]([C@H]1NC[C@H]([C@@](O)=O)C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-trans-2,4-PDC

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	15.91	100

Preparing Stock Solutions for L-trans-2,4-PDC

The following data is based on the product molecular weight 159.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.28 mL	31.42 mL	62.84 mL
5 mM	1.26 mL	6.28 mL	12.57 mL
10 mM	0.63 mL	3.14 mL	6.28 mL
50 mM	0.13 mL	0.63 mL	1.26 mL

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References for L-trans-2,4-PDC

References are publications that support the biological activity of the product.

Zuiderwijk Effects of uptake carrier blockers SK & F 89976-A and L-trans-PDC on in vivo release of amino acids in rat hippocampus. Eur.J.Pharmacol. 1996 PMID: 8836615
Mitrovic and Johnston Regional differences in the inhibition of L-glutamate amd L-aspartate sodium-dependent high affinity uptake systems in rat CNS synaptosomes by L-trans-pyrrolidine-2,4-dicarboxylic threo-3-hydroxy-D-aspartate and D-aspartate. Neurochem.Int. 1994 PMID: 7981641
Bridges Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer. J.Med.Chem. 1991 PMID: 1671706

Citations for L-trans-2,4-PDC (4)

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Citations are publications that use Bio-Techne products. Selected citations for L-trans-2,4-PDC include:

Yin and Weiss (2012) Marked synergism between mutant SOD1 and glutamate transport inhibition in the induction of motor neuronal degeneration in spinal cord slice cultures. Brain Res. 1448:153
PMID: 22370146
Heinrich et al. (2012) K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study. Br J Pharmacol. 167:1003
PMID: 22394324
Beaulé et al. (2009) Circadian modulation of gene expression, but not glutamate uptake, in mouse and rat cortical astrocytes. PLoS One. 4:e7476
PMID: 19829696
Young et al. (2007) Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex. PLoS One. 26:78
PMID: 17240155

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Showing 1 - 4 of 4 citations Showing All

Product Documents for L-trans-2,4-PDC

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.