L-(-)-threo-3-Hydroxyaspartic acid

Name: L-(-)- threo -3-Hydroxyaspartic acid
Brand: tocris
SKU: 0183

Catalog # 0183

Citations (1)

Datasheet / COA / SDS

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Key Product Details

Description:	Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor
Alternative Names:	L-threo-β-Hydroxyaspartic acid
Purity:	≥97% (HPLC)
Molecular Weight:	149.1

View Full Technical Details for L-(-)-threo-3-Hydroxyaspartic acid

Biological Activity

L-(-)-threo-3-Hydroxyaspartic acid is a potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™.

Technical Data

M. Wt	149.1
Formula	C₄H₇NO₅
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	7298-99-9
PubChem ID	443239
InChi Key	YYLQUHNPNCGKJQ-LWMBPPNESA-N
Smiles	[H][C@@]([C@]([H])(O)C(O)=O)(N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH		100

Preparing Stock Solutions

The following data is based on the product molecular weight 149.1.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.71 mL	33.53 mL	67.07 mL
5 mM	1.34 mL	6.71 mL	13.41 mL
10 mM	0.67 mL	3.35 mL	6.71 mL
50 mM	0.13 mL	0.67 mL	1.34 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Johnston Potentiation of L-glutamate and L-aspartate excitation of cat spinal neurones by the stereoisomers of threo-3-hydroxyaspartate. J.Neurochem. 1980 PMID: 7452241
McBean and Roberts Neurotoxicity of L-glutamate and DL-threo-3-hydroxyaspartate in the rat striatum. J.Neurochem. 1985 PMID: 2856883
Nakamura (2S,3S,4R)-2-(carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate. Neuropharmacology 1993 PMID: 7901789

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for L-(-)-threo-3-Hydroxyaspartic acid include:

Nakade et al. (2018) Gut microbiota-derived D-serine protects against acute kidney injury. JCI Insight. 3
PMID: 30333299

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Product Documents

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

L-(-)-threo-3-Hydroxyaspartic acid

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Key Product Details

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Biological Activity

Technical Data

Solubility

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Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations (1)

Product Documents

COA

Certificate of Analysis

SDS

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