L-(-)-threo-3-Hydroxyaspartic acid

Name: L-(-)- threo -3-Hydroxyaspartic acid
Brand: Tocris Bioscience
SKU: 0183

Catalog # 0183

Citations (1)

COA / SDS

Order Information

Bio-Techne Corporation

tel: (800) 343-7475 (free phone)

tel: (612) 379-2956

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

View Distributors

Key Product Details

Description:	Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor
Alternative Names:	L-threo-β-Hydroxyaspartic acid
Purity:	≥97% (HPLC)
Molecular Weight:	149.1

View Full Technical Details for L-(-)-threo-3-Hydroxyaspartic acid

Biological Activity

L-(-)-threo-3-Hydroxyaspartic acid is a potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor.

Technical Data

M. Wt	149.1
Formula	C₄H₇NO₅
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	7298-99-9
PubChem ID	443239
InChi Key	YYLQUHNPNCGKJQ-LWMBPPNESA-N
Smiles	[H][C@@]([C@]([H])(O)C(O)=O)(N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH		100

Preparing Stock Solutions

The following data is based on the product molecular weight 149.1.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.71 mL	33.53 mL	67.07 mL
5 mM	1.34 mL	6.71 mL	13.41 mL
10 mM	0.67 mL	3.35 mL	6.71 mL
50 mM	0.13 mL	0.67 mL	1.34 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

Nakamura (2S,3S,4R)-2-(carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate. Neuropharmacology 1993 PMID: 7901789
McBean and Roberts Neurotoxicity of L-glutamate and DL-threo-3-hydroxyaspartate in the rat striatum. J.Neurochem. 1985 PMID: 2856883
Johnston Potentiation of L-glutamate and L-aspartate excitation of cat spinal neurones by the stereoisomers of threo-3-hydroxyaspartate. J.Neurochem. 1980 PMID: 7452241

Citations for L-(-)-<em>threo</em>-3-Hydroxyaspartic acid (1)

Showing 1 - 1 of 1 citation Showing All

View all citations for the Small Molecules and Peptides platform.

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for L-(-)-threo-3-Hydroxyaspartic acid include:

Nakade et al. (2018) Gut microbiota-derived D-serine protects against acute kidney injury. JCI Insight. 3
PMID: 30333299

There are no citations that match your criteria.