L-NIO dihydrochloride

Name: L-NIO dihydrochloride
Brand: Tocris Bioscience
SKU: 0546
Price: 100 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 0546

Citations (8)

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Key Product Details

Description:	NOS inhibitor
Chemical Name:	N⁵-(1-Iminoethyl)-L-ornithine dihydrochloride
Molecular Weight:	246.13

View Full Technical Details for L-NIO dihydrochloride

Biological Activity for L-NIO dihydrochloride

L-NIO dihydrochloride is an Inhibitor of nitric oxide (NO) synthase. Inhibits iNOS, eNOS and nNOS. Active in vivo.

Technical Data for L-NIO dihydrochloride

M. Wt	246.13
Formula	C₇H₁₅N₃O₂.2HCl
Storage	Desiccate at -20°C
CAS Number	159190-44-0
PubChem ID	2733507
InChi Key	RYCMAAFECCXGHI-ILKKLZGPSA-N
Smiles	N[C@H](C(O)=O)CCCNC(C)=N.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-NIO dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	24.61	100

Preparing Stock Solutions for L-NIO dihydrochloride

The following data is based on the product molecular weight 246.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.06 mL	20.31 mL	40.63 mL
5 mM	0.81 mL	4.06 mL	8.13 mL
10 mM	0.41 mL	2.03 mL	4.06 mL
50 mM	0.08 mL	0.41 mL	0.81 mL

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References for L-NIO dihydrochloride

References are publications that support the biological activity of the product.

Moncada XIV. International Union of Pharmacology nomenclature in nitric oxide research. Pharmacol.Rev. 1997 PMID: 9228663
Mulligan Protective effects of inhibitors of nitric oxide synthase in immune complex-induced vasculitis. Br.J.Pharmacol. 1992 PMID: 1281719
Rees Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br.J.Pharmacol. 1990 PMID: 1706208

Citations for L-NIO dihydrochloride (8)

Showing 1 - 8 of 8 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for L-NIO dihydrochloride include:

Lu et al. (2015) Neuronal and Endothelial Nitric Oxide Synthases in the Paraventricular Nucleus Modulate Sympathetic Overdrive in Ins-Resistant Rats. Endocrinology. 10:e0140762
PMID: 26485682
Bergeron et al. (2015) Relaxin peptide hormones are protective during the early stages of ischemic stroke in male rats. PLoS Negl Trop Dis. 156:638
PMID: 25456068
Penumarti and Abdel-Rahman (2014) Neuronal nitric oxide synthase-dependent elevation in adiponectin in the rostral ventrolateral medulla underlies g protein-coupled receptor 18-mediated hypotension in conscious rats. J Pharmacol Exp Ther. 351:44
PMID: 25100751
Gross et al. (2013) Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. J Mol Cell Cardiol. 59:20
PMID: 23419451
Wu et al. (2013) Vasorelaxin: a novel arterial smooth muscle-relaxing eicosapeptide from the skin secretion of the Chinese piebald odorous frog (Odorrana schmackeri). PLoS One. 8:e55739
PMID: 23405205
Dai et al. (2011) Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS. Am J Physiol Heart Circ Physiol. 301:H1248
PMID: 21856924
Bender and Abdel-Rahman (2010) Differential central NOS-NO signaling underlies clon. exacerbation of ethanol-evoked behavioral impairment. Alcohol Clin Exp Res. 34:555
PMID: 20028349
Chang et al. (2002) Differential contributions of nitric oxide synthase isoforms at hippocampal formation to negative feedback regulation of penile erection in the rat. Br J Pharmacol. 136:43313
PMID: 11976262

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