L-NAME hydrochloride

Name: L-NAME hydrochloride
Brand: Tocris Bioscience
SKU: 0665
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 0665

Citations (20)

(1)

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Key Product Details

Description:	Non-selective NOS inhibitor
Chemical Name:	NG-Nitro-L-arginine methyl ester hydrochloride
Molecular Weight:	269.69

View Full Technical Details for L-NAME hydrochloride

Biological Activity for L-NAME hydrochloride

L-NAME hydrochloride is a NO synthase inhibitor.

Compound Libraries for L-NAME hydrochloride

L-NAME hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for L-NAME hydrochloride

M. Wt	269.69
Formula	C₇H₁₅N₅O₄.HCl
Storage	Store at RT
CAS Number	51298-62-5
PubChem ID	135193
InChi Key	QBNXAGZYLSRPJK-JEDNCBNOSA-N
Smiles	N=C(NCCC[C@H](N)C(OC)=O)N[N+]([O-])=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-NAME hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	26.97	100
	DMSO	26.97	100

Preparing Stock Solutions for L-NAME hydrochloride

The following data is based on the product molecular weight 269.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.71 mL	18.54 mL	37.08 mL
5 mM	0.74 mL	3.71 mL	7.42 mL
10 mM	0.37 mL	1.85 mL	3.71 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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Reconstitution Calculator

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References for L-NAME hydrochloride

References are publications that support the biological activity of the product.

Moore and Handy Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPS 1997 PMID: 9226999
Pfeiffer Inhibition of nitric oxide synthesis by N^G-nitro-L-arginine methyl ester (L-NAME): requirement for bioactivation to the free acid, N^G-nitro-L-arginine. Br.J.Pharmacol. 1996 PMID: 8832069
Knowles Nitric oxide synthases in mammals. Biochem.J. 1994 PMID: 7510950

Citations for L-NAME hydrochloride (20)

Showing 1 - 10 of 20 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for L-NAME hydrochloride include:

Cameron (2017) Structural and pharmacological basis for the induction of mitochondrial biogenesis by formo. but not clenbu. Sci Rep. 7(1):10578
PMID: 28874749
Cramer et al. (2015) Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse. Proc Natl Acad Sci U S A. 35:5664
PMID: 25855180
Bucher et al. (2014) Medullary NE neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab. 34:1128
PMID: 24714037
Bice et al. (2014) NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size. Cardiovasc Res. 101:220
PMID: 24259501
Gross et al. (2013) Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. J Mol Cell Cardiol. 59:20
PMID: 23419451
Orru et al. (2013) Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans. Neuropharmacology. 67:476
PMID: 23261866
Elks et al. (2013) Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism. PLoS Pathog. 9:e1003789
PMID: 24367256
Vaish and Singh (2013) Antioxidant Functions of Nitric Oxide Synthase in a Methicillin Sensitive Staphylococcus aureus. Br J Cancer. 2013:312146
PMID: 23690783
Townsend and Emala (2013) Quercetin acutely relaxes airway smooth muscle and potentiates β-agonist-induced relaxation via dual phosphodiesterase inhibition of PLCβ and PDE4. Am J Physiol Lung Cell Mol Physiol. 305:L396
PMID: 23873842
Dai et al. (2011) Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS. Am J Physiol Heart Circ Physiol. 301:H1248
PMID: 21856924
Gallo and Iadecola (2011) Neuronal nitric oxide contributes to neuroplasticity-associated protein expression through cGMP, protein kinase G, and extracellular signal-regulated kinase. J Neurosci. 31:6947
PMID: 21562256
Sunters et al. (2010) Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of Ins-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-i J Biol Chem. 285:8743
PMID: 20042609
Huang and Hsu (2010) Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex. 20:982
PMID: 19666830
Lou et al. (2009) Hydroxyurea generates nitric oxide in human erythroid cells: mechanisms for gamma-globin gene activation. Exp Biol Med (Maywood). 234:1374
PMID: 19657070
Pearson et al. (2009) Detection of EETs and HETE-generating cytochrome P-450 enzymes and the effects of their metabolites on myometrial and vascular function. Am J Physiol Endocrinol Metab. 297:E647
PMID: 19549792
Gibson et al. (2008) TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron. 57:746
PMID: 18341994
Silva et al. (2007) Melatonin inhibits nitric oxide production by microvascular endothelial cells in vivo and in vitro. Br J Pharmacol. 151:195
PMID: 17375079
Safo and Regehr (2005) Endocannabinoids control the induction of cerebellar LTD. Neuron. 48:647
PMID: 16301180
Chen et al. (2002) Development of a human neuronal cell model for human immunodeficiency virus (HIV)-infected macrophage-induced neurotoxicity: apoptosis induced by HIV type 1 primary isolates and evidence for involvement of the Bcl-2/Bcl-xL-sensitive intrinsic apoptosis pa J Virol. 76:9407
PMID: 12186923
Casado et al. (2000) Presynaptic N-MthD.-aspartate receptors at the parallel fiber-Purkinje cell synapse. Int J Microbiol. 97:11593
PMID: 11016958

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Effective nitric oxide synthase blocker

Name: Karthik krishnamurthy

Species: Rat

Cell Line/Tissue: astrocytes

Measured time lapse production of nitric oxide in astrocytes stimulated with 30 μM UTP with and without pretreatment with 100 μM L-NAME.

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