L-745,870 trihydrochloride

Name: L-745,870 trihydrochloride
Brand: Tocris Bioscience
SKU: 1002
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1002

(1)

Citations (37)

COA / SDS

Highly selective D4 antagonist

Key Product Details

Description:	Highly selective D₄ antagonist
Chemical Name:	3-(4-[4-Chlorophenyl]piperazin-1-yl)-methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	436.21

View Full Technical Details for L-745,870 trihydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for L-745,870 trihydrochloride

L-745,870 trihydrochloride is a highly potent and selective D₄ dopamine receptor antagonist; L-745,870 has K_i values of 0.51, 2300 and 960 nM for D₄, D₃ and D₂ subtypes respectively and > 1000-fold selectivity over 5-HT₂, D₁ and D₅ receptors.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data for L-745,870 trihydrochloride

M. Wt	436.21
Formula	C₁₈H₁₉N₄Cl.3HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	866021-03-6
PubChem ID	49759035
InChi Key	KJSOYZLYCFYXFC-UHFFFAOYSA-N
Smiles	Cl.Cl.Cl.ClC1=CC=C(C=C1)N1CCN(CC2=CNC3=NC=CC=C23)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-745,870 trihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	43.62	100

Preparing Stock Solutions for L-745,870 trihydrochloride

The following data is based on the product molecular weight 436.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.29 mL	11.46 mL	22.92 mL
5 mM	0.46 mL	2.29 mL	4.58 mL
10 mM	0.23 mL	1.15 mL	2.29 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for L-745,870 trihydrochloride

References are publications that support the biological activity of the product.

Pillai Human D2 and D4 DA receptors couple through βγ G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system: selective antagonism by L-741,626 and L-745,870 respect Neuropharmacology 1998 PMID: 9833627
Kulagowski 3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine: an antagonist with high affinity and selectivity for the human D₄ receptor. J.Med.Chem. 1996 PMID: 8642550
Patel Biological profile of L-745,870, a selective antagonist with high affinity for the DA D₄ receptor. J.Pharmacol.Exp.Ther. 1997 PMID: 9353380
Bristow Schizophrenia and L-745, 870 a novel DA D₄ receptor antagonist. TiPS 1997 PMID: 9226994